Results 11 to 20 of about 202,778 (267)

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Genome Medicine, 2018
Background The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations ...
Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Narendra Padhan, Jimmy Larsson, Maria Karoutsou, Kenneth Ban, Jacek R. Wiśniewski, Per Artursson, Liqun He, Mats Hellström, Tobias Sjöblom   +11 more
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Ras-induced changes in H3K27me3 occur after those in transcriptional activity. [PDF]

PLoS Genetics, 2013
Oncogenic signaling pathways regulate gene expression in part through epigenetic modification of chromatin including DNA methylation and histone modification.
Masaki Hosogane, Ryo Funayama, Yuichiro Nishida, Takeshi Nagashima, Keiko Nakayama   +4 more
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The RASopathies: from pathogenetics to therapeutics

Disease Models & Mechanisms, 2022
The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello ...
Katie E. Hebron, Edjay Ralph Hernandez, Marielle E. Yohe   +2 more
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Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide.

PLoS ONE, 2020
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable.
Seyhan Turk, Can Turk, Muhammad Waqas Akbar, Baris Kucukkaraduman, Murat Isbilen, Secil Demirkol Canli, Umit Yavuz Malkan, Mufide Okay, Gulberk Ucar, Nilgun Sayinalp, Ibrahim Celalettin Haznedaroglu, Ali Osmay Gure   +11 more
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Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes

Scientific Reports, 2018
In contrast to amniotes (reptiles, birds and mammals), anamniotes (fishes and amphibians) can effectively regenerate body appendages such as fins, limbs and tails. Why such a useful capability was progressively lost in amniotes remains unknown.
Anastasiya S. Ivanova, Daria D. Korotkova, Galina V. Ermakova, Natalia Yu. Martynova, Andrey G. Zaraisky, Maria B. Tereshina   +5 more
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A Novel Ras--Related Signature Improves Prognostic Capacity in Oesophageal Squamous Cell Carcinoma

Frontiers in Genetics, 2022
Oesophageal squamous cell carcinoma (ESCC) remains a clinically challenging disease with high morbidity rates and poor prognosis. ESCC is also the most common pathological type of oesophageal cancer (EC) in China.
Hao-Shuai Yang, Wei Liu, Shao-Yi Zheng, He-Yuan Cai, Hong-He Luo, Yan-Fen Feng, Yan-Fen Feng, Yi-Yan Lei   +7 more
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n-ras and k-ras Mutations Among Some Iraqi Patients with Acute Lymphoblastic Leukemia

Kufa Journal for Veterinary Medical Sciences, 2016
Somatic mutations which influence the activity of RAS genes, n-, h-, and k-ras, are recognized mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers.
Wiaam Ahmed Al-Amili, Abdul Hussein Moyet l Al-Faisa, Norrya Abdul Hussein, Khalid Tobal   +3 more
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Shenkang injection improves chronic kidney disease by inhibiting multiple renin-angiotensin system genes by blocking the Wnt/β-catenin signalling pathway

Frontiers in Pharmacology, 2022
Chronic kidney disease (CKD) is a major worldwide public health problem. The increase in the number of patients with CKD and end-stage kidney disease requesting renal dialysis or transplantation will progress to epidemic proportions in the next several ...
Yan-Ni Wang, Hong-Jiao Liu, Li-Li Ren, Ping Suo, Liang Zou, Ya-Mei Zhang, Xiao-Yong Yu, Ying-Yong Zhao, Ying-Yong Zhao, Ying-Yong Zhao   +9 more
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Targeting K-Ras-mediated DNA damage response in radiation oncology: Current status, challenges and future perspectives

Clinical and Translational Radiation Oncology, 2023
Approximately 60% of cancer patients receive curative or palliative radiation. Despite the significant role of radiotherapy (RT) as a curative approach for many solid tumors, tumor recurrence occurs, partially because of intrinsic radioresistance ...
Mahmoud Toulany
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Extracranial Vascular Anomalies Driven by RAS/MAPK Variants: Spectrum and Genotype–Phenotype Correlations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to correlate alterations in the rat sarcoma virus (RAS)/mitogen‐activated protein kinase pathway in vascular anomalies to the clinical phenotype for improved patient and treatment stratification. Methods and Results This retrospective
Vanessa F. Schmidt, Friedrich G. Kapp, Constantin Goldann, Linda Huthmann, Beatrix Cucuruz, Richard Brill, Veronika Vielsmeier, Caroline T. Seebauer, Armin‐Johannes Michel, Max Seidensticker, Wibke Uller, Jakob B. W. Weiß, Alena Sint, Beate Häberle, Julia Haehl, Alexandra Wagner, Johanna Cordes, Annegret Holm, Denny Schanze, Jens Ricke, Melanie A. Kimm, Walter A. Wohlgemuth, Martin Zenker, Moritz Wildgruber   +23 more
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