Results 11 to 20 of about 211,660 (314)

The common rejection module in chronic rejection post lung transplantation. [PDF]

PLoS ONE, 2018
RATIONALE:Recent studies suggest that similar injury mechanisms are in place across different solid organ transplants, resulting in the identification of a common rejection module (CRM), consisting of 11 genes that are overexpressed during acute and, to ...
Annelore Sacreas, Joshua Y C Yang, Bart M Vanaudenaerde, Tara K Sigdel, Juliane M Liberto, Izabella Damm, Geert M Verleden, Robin Vos, Stijn E Verleden, Minnie M Sarwal   +9 more
doaj   +1 more source

K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity [PDF]

, 2011
A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amongst
Samuel, M., Lourenco, F., Michael S Samuel, Filipe C Lourenço, Olson, M.F., Michael F Olson, Filipe C. Lourenço, Samuel Michael S., Olson Michael F., Samuel, M.S., Lourenço, F.C., Michael S. Samuel, Lourenço Filipe C., Olson, M., Michael F. Olson   +14 more
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Ras-induced EpCAM and several other membrane proteins.

, 2023
A. Microarray data (GSE12777) for 51 breast cancer cell line was analyzed using Gene-E software. E-cadherin correlated 121 genes are enriched in first step followed by EpCAM close (correlated). These genes are presented in normal and Ras-transduced cells
Narendra V. Sankpal (15082659), Timothy P. Fleming (10677614), Taylor C. Brown (10791184), Fatma A. Omar (15503723), Michael A. Smith (280181), William E. Gillanders (10677623), Ross M. Bremner (8968232)   +6 more
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A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. [PDF]

PLoS Genetics, 2018
Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to identify cooperating cancer-relevant signaling pathways.
Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Xia Cuiping, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane J F Cronin, G Gregory Neely, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger   +18 more
doaj   +1 more source

Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

Genome Medicine, 2018
Background The Ras pathway genes KRAS, BRAF, or ERBBs have somatic mutations in ~ 60% of human colorectal carcinomas. At present, it is unknown whether the remaining cases lack mutations activating the Ras pathway or whether they have acquired mutations ...
Snehangshu Kundu, Muhammad Akhtar Ali, Niklas Handin, Narendra Padhan, Jimmy Larsson, Maria Karoutsou, Kenneth Ban, Jacek R. Wiśniewski, Per Artursson, Liqun He, Mats Hellström, Tobias Sjöblom   +11 more
doaj   +1 more source

Ras-induced changes in H3K27me3 occur after those in transcriptional activity. [PDF]

PLoS Genetics, 2013
Oncogenic signaling pathways regulate gene expression in part through epigenetic modification of chromatin including DNA methylation and histone modification.
Masaki Hosogane, Ryo Funayama, Yuichiro Nishida, Takeshi Nagashima, Keiko Nakayama   +4 more
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The RASopathies: from pathogenetics to therapeutics

Disease Models & Mechanisms, 2022
The RASopathies are a group of disorders caused by a germline mutation in one of the genes encoding a component of the RAS/MAPK pathway. These disorders, including neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous syndrome, Costello ...
Katie E. Hebron, Edjay Ralph Hernandez, Marielle E. Yohe   +2 more
doaj   +1 more source

Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide.

PLoS ONE, 2020
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable.
Seyhan Turk, Can Turk, Muhammad Waqas Akbar, Baris Kucukkaraduman, Murat Isbilen, Secil Demirkol Canli, Umit Yavuz Malkan, Mufide Okay, Gulberk Ucar, Nilgun Sayinalp, Ibrahim Celalettin Haznedaroglu, Ali Osmay Gure   +11 more
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Mutations in APC, CTNNBI and K-ras genes and expression of hMLHI in sporadic colorectal carcinomas from the Netherlands Cohort Study [PDF]

, 2005
22.08.14 KB.
de Goeij, AFPM, de Bruïne Adriaan P, Luchtenborg, M, Saritas A Merdan, van Muijen, Goos NP, Saritas, AM, Weijenberg, MP, van Muijen, GNP, Saritas, A.M., Weijenberg, Matty P., Piet A van den Brandt, Roemen, GMJM, Adriaan P de Bruïne, de Goeij, Anton F P M, Wark, P.A., de Goeij Anton FPM, van Muijen, G.N.P., de Bruine, AP, de Bruine, A.P., Anton FPM de Goeij, de Bruïne, Adriaan P., Matty P Weijenberg, Lüchtenborg, Margreet, Margreet Lüchtenborg, van Muijen Goos NP, Roemen, G.M., A Merdan Saritas, Roemen, Guido M J M, Brandt, P.A. van den, Saritas, A. Merdan, Wark, PA, Wark Petra A, Muijen, G.N.P. van, Saritas, A Merdan, van den Brandt, Piet A, Weijenberg Matty P, Wark, Petra A.; id_orcid, van den Brandt, PA, Goos NP van Muijen, Weijenberg, Matty P, Roemen, G.M.J.M., van den Brandt, Piet A., de Bruïne, Adriaan P, van den Brandt Piet A, Guido MJM Roemen, de Goeij, Anton FPM, Lüchtenborg Margreet, Merdan Saritas, M., Bruine, A.P. de, van den Brandt, P.A., Luchtenborg, M., Goeij, A.F. de, Weijenberg, M.P., Wark, Petra A, Roemen Guido MJM, Roemen, Guido MJM, Petra A Wark, de Goeij, A.F., van Muijen, Goos N P   +58 more
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Ras-dva small GTPases lost during evolution of amniotes regulate regeneration in anamniotes

Scientific Reports, 2018
In contrast to amniotes (reptiles, birds and mammals), anamniotes (fishes and amphibians) can effectively regenerate body appendages such as fins, limbs and tails. Why such a useful capability was progressively lost in amniotes remains unknown.
Anastasiya S. Ivanova, Daria D. Korotkova, Galina V. Ermakova, Natalia Yu. Martynova, Andrey G. Zaraisky, Maria B. Tereshina   +5 more
doaj   +1 more source