Results 1 to 10 of about 223,519 (257)
The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis [PDF]
Cells, 2018 The exploitation of the yeast Saccharomyces cerevisiae as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries.
Giulia Cazzanelli +11 more
doaj +4 more sources
The ubiquitin code of RAS proteins: Decoding its role in cancer progression [PDF]
iScienceSummary: RAS proteins, as the most frequently mutated oncoproteins in human cancers, drive tumor proliferation, metastasis, and therapeutic resistance.
Yedan Shi +6 more
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Monoterpene regulation of Ras and Ras-related protein expression [PDF]
Journal of Lipid Research, 2003 Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined.
Sarah A. Holstein, Raymond J. Hohl
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Posttranslational Modifications of RAS Proteins. [PDF]
Cold Spring Harb Perspect Med, 2018 The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting.
Ahearn I, Zhou M, Philips MR.
europepmc +4 more sources
Membrane Fusion and SNAREs: Interaction with Ras Proteins [PDF]
International Journal of Molecular Sciences, 2022 Azzurra Margiotta
exaly +2 more sources
Post-translational modification of RAS proteins [PDF]
Current Opinion in Structural Biology, 2021 Philips Mark, Sharon Campbell
exaly +2 more sources
Small molecule inhibitors of RAS proteins with oncogenic mutations [PDF]
Cancer and Metastasis Reviews, 2020 György M Keserű +2 more
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RAS Proteins and Their Regulators in Human Disease [PDF]
Cell, 2017 Dwight V Nissley +2 more
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Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy [PDF]
Pharmaceutical Sciences, 2022 Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways.
Jeiran Pashapour-Anousheh +5 more
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Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
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