Results 1 to 10 of about 228,408 (116)
The ubiquitin code of RAS proteins: Decoding its role in cancer progression [PDF]
iScienceSummary: RAS proteins, as the most frequently mutated oncoproteins in human cancers, drive tumor proliferation, metastasis, and therapeutic resistance.
Yedan Shi +6 more
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Identification of novel serum proteins that distinguish idiopathic recurrent aphthous stomatitis from Behcet’s disease [PDF]
PeerJBackground Recurrent aphthous stomatitis (RAS) is a chronic autoinflammatory condition marked by recurring, painful sores in the mouth. It is often confused with Behcet’s disease (BD), a rare systemic vasculitis that also presents with oral ulcers ...
Mengya Zhu +8 more
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The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis [PDF]
Cells, 2018 The exploitation of the yeast Saccharomyces cerevisiae as a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries.
Giulia Cazzanelli +11 more
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RAS Proteins and Their Regulators in Human Disease. [PDF]
Cell, 2017 Simanshu DK, Nissley DV, McCormick F.
europepmc +2 more sources
Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy [PDF]
Pharmaceutical Sciences, 2022 Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways.
Jeiran Pashapour-Anousheh +5 more
doaj +1 more source
Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
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Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
Animal Cells and Systems, 2021 There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon +2 more
doaj +1 more source
RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
Frontiers in Molecular Biosciences, 2021 RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer. In
Yong Zhou +2 more
doaj +1 more source
Cell Communication and Signaling, 2021 Background Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1).
Shannon M. Weber +7 more
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Neoplasia: An International Journal for Oncology Research, 2022 Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene.
Chitra Palanivel +6 more
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