Results 31 to 40 of about 372,429 (303)

Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements

European Journal of Cell Biology, 2023
The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane.
Ganesh babu Manoharan, Camilo Guzmán, Arafath Kaja Najumudeen, Daniel Abankwa   +3 more
doaj   +1 more source

Ras signaling through RASSF proteins [PDF]

Seminars in Cell & Developmental Biology, 2016
There are six core RASSF family proteins that contain conserved Ras Association domains and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function as scaffolding and localization molecules. While initially being associated with pro-apoptotic signaling pathways such as Bax and Hippo, it is now clear that they can also ...
Howard, Donninger, M Lee, Schmidt, Jessica, Mezzanotte, Thibaut, Barnoud, Geoffrey J, Clark   +4 more
openaire   +2 more sources

Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme

Molecular Therapy: Oncolytics, 2023
Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors.
Valentina Palacio-Castañeda, Bas van de Crommert, Elke Verploegen, Mike Overeem, Jenny van Oostrum, Wouter P.R. Verdurmen   +5 more
doaj   +1 more source

Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

eLife, 2018
While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells ...
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells   +10 more
doaj   +1 more source

A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.

PLoS Genetics, 2020
Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer.
Chalita Washington, Rachel Chernet, Rewatee H Gokhale, Yesenia Martino-Cortez, Hsiu-Yu Liu, Ashley M Rosenberg, Sivan Shahar, Cathie M Pfleger   +7 more
doaj   +1 more source

Targeting Ras with protein engineering

Oncotarget, 2023
Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras's mostly flat surface and lack of small molecule ...
Tomazini, Atilio, Shifman, Julia M.
openaire   +2 more sources

Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II [PDF]

, 2004
synGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalian forebrain. Proteins in the postsynaptic density, including synGAP, are part of a signaling complex attached to the ...
Kennedy, Mary B., Manzerra, Pasquale, Oh, Jeong S.   +2 more
core   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source

Ras Enhances Myc Protein Stability [PDF]

Molecular Cell, 1999
Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal cell growth control as well as during oncogenesis. We now show that Ras enhances the accumulation of Myc activity by stabilizing the Myc protein. Whereas Myc has a very short half-life when produced in the absence of mitogenic signals, due to degradation by the ...
Sears, Rosalie, Leone, Gustavo, DeGregori, James, Nevins, Joseph R   +3 more
openaire   +2 more sources

Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. [PDF]

, 2014
The renin-angiotensin system (RAS), bone morphogenetic protein (BMP), and WNT pathways are involved in pathogenesis of diabetic kidney disease (DKD).
Afkarian, Maryam, de Boer, Ian H, Greenbaum, Carla, Himmelfarb, Jonathan, Hirsch, Irl B, Tuttle, Katherine R   +5 more
core   +1 more source