Results 51 to 60 of about 232,899 (308)

A Comparative Analysis of Individual RAS Mutations in Cancer Biology

Frontiers in Oncology, 2019
In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode four highly homologous proteins. RAS proteins are small GTPases involved in a broad spectrum of key molecular and cellular activities, including proliferation and ...
Carmen Muñoz-Maldonado, Carmen Muñoz-Maldonado, Yitzhak Zimmer, Yitzhak Zimmer, Michaela Medová, Michaela Medová   +5 more
doaj   +1 more source

TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization

Scientific Reports, 2022
In the course of cancer progression tumor cells undergo morphological changes that lead to increased motility and invasiveness thus promoting formation of metastases.
Alexandros Damalas, Ivana Vonkova, Marijonas Tutkus, Dimitrios Stamou   +3 more
doaj   +1 more source

The energetics of nucleotide binding to RAS proteins

, 1992
Ras proteins are a special class of proteins that mediate cell growth signals. Their importance lies in the fact that they are products of a proto-oncogene.
Worth, Graham A., Worth, Graham Alan.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RAS-effector interaction hotspots.

, 2016
(A) Interaction matrix of RAS isoforms and effector proteins. Interaction matrix is launched to demonstrate interaction residues in all available structures (see Fig 3 and S4 Fig).
Mohammad Reza Ahmadian (596739), Hossein Nakhaeizadeh (3390107), Ehsan Amin (832281), Radovan Dvorsky (832280), Saeideh Nakhaei-Rad (3390110)   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras^V12 mutated protein and the E1A oncogene

Molecular Cancer, 2003
Background Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important.
Berthezene Patrice, Labrie Claude, Calvo Ezequiel L, Malicet Cédric, Vasseur Sophie, Dagorn Jean, Iovanna Juan   +6 more
doaj   +1 more source

An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients [PDF]

, 2008
Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters.
Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S., Edwards, J.   +5 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source