Results 41 to 50 of about 372,429 (303)
κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation
Cell Reports, 2014 The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and
Andrea Oeckinghaus +9 more
doaj +1 more source
Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]
, 2016 Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris +7 more
core +2 more sources
The Ins and Outs of RAS Effector Complexes
Biomolecules, 2021 RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status.
Christina Kiel +2 more
doaj +1 more source
The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]
, 2009 Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Davey, John +3 more
core +2 more sources
Effect of amaranth proteins on the RAS system: In vitro, in vivo and ex vivo assays [PDF]
, 2020 The aim of this work was to analyse the hypotensive effect of amaranthprotein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo.
Aphalo, Paula +4 more
core +2 more sources
PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!
Journal of Orofacial Sciences, 2014 Background: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell ...
Natheer H Al-Rawi +2 more
doaj +1 more source
Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]
, 2018 More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian +7 more
core +1 more source
Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis
Redox Biology, 2015 We previously reported that oncogenic KRAS activation of the PI3K/AKT pathway stimulates the remaining wild-type HRAS and NRAS proteins in a manner dependent upon both eNOS expression and C118 in HRAS and NRAS, which promoted tumor growth.
Chris Counter
doaj +1 more source
eLife, 2020 The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-domains.
Debanjan Goswami +17 more
doaj +1 more source
RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site
Nature Communications, 2021 Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools to ...
Katarzyna Z. Haza +20 more
doaj +1 more source