Results 21 to 30 of about 228,557 (259)
Regulation of Ras Signaling by S-Nitrosylation
Antioxidants, 2023 Ras are a family of small GTPases that function as signal transduction mediators and are involved in cell proliferation, migration, differentiation and survival.
Sónia Simão +3 more
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Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme
Molecular Therapy: Oncolytics, 2023 Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors.
Valentina Palacio-Castañeda +5 more
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Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators
Acta Pharmaceutica Sinica B, 2021 RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the ...
Yuran Qiu +10 more
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eLife, 2018 While there have been tremendous efforts to target oncogenic RAS signaling from inside the cell, little effort has focused on the cell-surface. Here, we used quantitative surface proteomics to reveal a signature of proteins that are upregulated on cells ...
Alexander J Martinko +10 more
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A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5.
PLoS Genetics, 2020 Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer.
Chalita Washington +7 more
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κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation
Cell Reports, 2014 The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and
Andrea Oeckinghaus +9 more
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Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo [PDF]
Journal of Biological Chemistry, 1998 Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo.
M K, Jones, J H, Jackson
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The Ins and Outs of RAS Effector Complexes
Biomolecules, 2021 RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status.
Christina Kiel +2 more
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Analysis of mutant Ras proteins [PDF]
Biochemistry and Molecular Biology Education, 2007 AbstractTerms to be familiar with before you start to solve the test: growth‐factor signaling; Ras proteins; Raf proteins; G proteins; protein kinases; GTPase; GEFs (guanine nucleotide exchange factors); GAPs (GTPase activating proteins); transfection; expression plasmid; mitogen‐activated protein kinase (MAPK); extracellular signal‐regulated kinase ...
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PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!
Journal of Orofacial Sciences, 2014 Background: PIK3 and K-ras are signal transducing proteins involved and mediating many responses related to cell cycle growth regulation. Until date, there has been only limited evidence about the expression of K-ras and PKI3CB in oral squamous cell ...
Natheer H Al-Rawi +2 more
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