Results 21 to 30 of about 232,899 (308)
K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity [PDF]
, 2011 A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amongst
Samuel, M. +14 more
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Ras-induced EpCAM and several other membrane proteins.
, 2023 A. Microarray data (GSE12777) for 51 breast cancer cell line was analyzed using Gene-E software. E-cadherin correlated 121 genes are enriched in first step followed by EpCAM close (correlated). These genes are presented in normal and Ras-transduced cells
Narendra V. Sankpal (15082659) +6 more
core +1 more source
Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
doaj +1 more source
The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]
, 2009 Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Ladds, Graham +3 more
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Regulation of Ras Signaling by S-Nitrosylation
Antioxidants, 2023 Ras are a family of small GTPases that function as signal transduction mediators and are involved in cell proliferation, migration, differentiation and survival.
Sónia Simão +3 more
doaj +1 more source
Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
PLoS ONE, 2011 BackgroundReceptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on ...
Tobias Sperka +6 more
doaj +1 more source
Drug targeting opportunities en route to Ras nanoclusters.
, 2022 peer reviewedDisruption of the native membrane organization of Ras by the farnesyltransferase inhibitor tipifarnib in the late 1990s constituted the first indirect approach to drug target Ras. Since then, our understanding of how dynamically Ras shuttles
CHIPPALKATTI, Rohan +5 more
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Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme
Molecular Therapy: Oncolytics, 2023 Despite decades of efforts, an urgent need remains to develop tumor cell-selective rat sarcoma (Ras)-targeting therapies that can treat patients with Ras-driven tumors.
Valentina Palacio-Castañeda +5 more
doaj +1 more source
On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]
, 2004 Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
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Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators
Acta Pharmaceutica Sinica B, 2021 RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the ...
Yuran Qiu +10 more
doaj +1 more source