Results 11 to 20 of about 228,557 (259)
Monoterpene regulation of Ras and Ras-related protein expression [PDF]
Journal of Lipid Research, 2003 Monoterpenes, derived primarily from plants, are products of the isoprenoid biosynthetic pathway and function as chemical messengers with diverse functions. The biochemical bases for these activities are largely undefined.
Sarah A. Holstein, Raymond J. Hohl
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Posttranslational Modifications of RAS Proteins. [PDF]
Cold Spring Harb Perspect Med, 2018 The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting.
Ahearn I, Zhou M, Philips MR.
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Compartmentalization of Ras proteins [PDF]
Journal of Cell Science, 2001 ABSTRACT The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms
Prior, I. A., Hancock, J. F.
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RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
Biomolecules, 2021 RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellular ...
Que N. Van +5 more
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The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways. [PDF]
PLoS ONE, 2011 Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini.
Clara L Oeste +10 more
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Targeting Ras with protein engineering
Oncotarget, 2023 Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated with many types of cancer, making them attractive targets for cancer therapy. Despite extensive efforts, targeting Ras proteins with small molecules has been extremely challenging due to Ras's mostly flat surface and lack of small molecule ...
Tomazini, Atilio, Shifman, Julia M.
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The Role and Function of Ras-association domain family in Cancer: A Review
Genes and Diseases, 2019 Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP.
Mohammad Reza Zinatizadeh +7 more
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Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
European Journal of Cell Biology, 2023 The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane.
Ganesh babu Manoharan +3 more
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Journal of Lipid Research, 2006 Proteins that terminate with a consensus sequence known as CAAX undergo a series of posttranslational modifications that include polyisoprenylation, endoproteolysis, and carboxyl methylation.
Latasha P. Wright, Mark R. Philips
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Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.
PLoS ONE, 2011 BackgroundReceptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on ...
Tobias Sperka +6 more
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