Results 11 to 20 of about 223,519 (257)
Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
Animal Cells and Systems, 2021 There are three Rap proteins in Dictyostelium. RapA is a key regulator of cell adhesion and cytoskeletal rearrangement. Recently, RapC has been reported to be involved in cytokinesis, cell migration, and multicellular development.
Jihyeon Jeon +2 more
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RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains
Frontiers in Molecular Biosciences, 2021 RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer. In
Yong Zhou +2 more
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Cell Communication and Signaling, 2021 Background Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1).
Shannon M. Weber +7 more
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Neoplasia: An International Journal for Oncology Research, 2022 Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene.
Chitra Palanivel +6 more
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Compartmentalization of Ras proteins [PDF]
Journal of Cell Science, 2001 ABSTRACT The Ras GTPases operate as molecular switches that link extracellular stimuli with a diverse range of biological outcomes. Although many studies have concentrated on the protein-protein interactions within the complex signaling cascades regulated by Ras, it is becoming clear that the spatial orientation of different Ras isoforms
Prior, I. A., Hancock, J. F.
openaire +4 more sources
RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention
Biomolecules, 2021 RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellular ...
Que N. Van +5 more
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The C-terminus of H-Ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways. [PDF]
PLoS ONE, 2011 Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their C-termini.
Clara L Oeste +10 more
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The Role and Function of Ras-association domain family in Cancer: A Review
Genes and Diseases, 2019 Ras gene mutation has been observed in more than 30% of cancers, and 90% of pancreatic, lung and colon cancers. Ras proteins (K-Ras, H-Ras, N-Ras) act as molecular switches which are activated by binding to GTP.
Mohammad Reza Zinatizadeh +7 more
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Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements
European Journal of Cell Biology, 2023 The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane.
Ganesh babu Manoharan +3 more
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Identification of novel serum proteins that distinguish idiopathic recurrent aphthous stomatitis from Behcet’s disease [PDF]
PeerJBackground Recurrent aphthous stomatitis (RAS) is a chronic autoinflammatory condition marked by recurring, painful sores in the mouth. It is often confused with Behcet’s disease (BD), a rare systemic vasculitis that also presents with oral ulcers ...
Mengya Zhu +8 more
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