Results 61 to 70 of about 372,429 (303)

TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization

Scientific Reports, 2022
In the course of cancer progression tumor cells undergo morphological changes that lead to increased motility and invasiveness thus promoting formation of metastases.
Alexandros Damalas, Ivana Vonkova, Marijonas Tutkus, Dimitrios Stamou   +3 more
doaj   +1 more source

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters [PDF]

, 2013
Lipid-anchored Ras GTPases form transient, spatially segregated nanoclusters on the plasma membrane that are essential for high-fidelity signal transmission. The lipid composition of Ras nanoclusters however has not previously been investigated.
Abankwa, Abankwa, Andresen, Ariotti, Baumgart, Brown, Brown, Casey, Cho, Deschout, Diggle, Dougherty, Epand, Garcia, Garg, Ghosh, Goldenberg, Gorfe, Gowrishankar, Grande-Garcia, Gutierrez, Hammond, Hancock, Hancock, Hancock, Hancock, Hill, Hong Liang, Jaumot, John F. Hancock, Kale, Kalwa, Kay, Kholodenko, Kiselev, Kiselev, Lee, Miao, Mor, Murakoshi, Nicholas Ariotti, Plowman, Plowman, Prior, Prior, Prior, Prior, Robert G. Parton, Rotblat, Roy, Schroeder, Sharma, Tian, Tian, Travis Rodkey, Treeck, van der Hoeven, van Rheenen, Veatch, Veatch, Voice, Yan, Yeung, Yong Zhou, Zeniou-Meyer, Zhou   +65 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras^V12 mutated protein and the E1A oncogene

Molecular Cancer, 2003
Background Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important.
Berthezene Patrice, Labrie Claude, Calvo Ezequiel L, Malicet Cédric, Vasseur Sophie, Dagorn Jean, Iovanna Juan   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Analysis of mutant Ras proteins [PDF]

Biochemistry and Molecular Biology Education, 2007
AbstractTerms to be familiar with before you start to solve the test: growth‐factor signaling; Ras proteins; Raf proteins; G proteins; protein kinases; GTPase; GEFs (guanine nucleotide exchange factors); GAPs (GTPase activating proteins); transfection; expression plasmid; mitogen‐activated protein kinase (MAPK); extracellular signal‐regulated kinase ...
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamics of Ras Complexes Observed in Living Cells

Sensors, 2012
K-Ras works as a switch in many important intracellular signaling pathways and plays important roles in cell growth, proliferation, differentiation and carcinogenesis.
Xiangyong Li, Zhiyong Cheng, Honglin Jin
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source