Results 131 to 140 of about 1,281 (194)
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
ẢNH HƯỞNG CỦA CHỦNG VI KHUẨN NỐT RỄ VÀ VI KHUẨN PSEUDOMONAS SPP. TRÊN LÚA CAO SẢN TRỒNG TRÊN ĐẤT PHÙ SA CẦN THƠ [PDF]
, 2005 Một dòng vi khuẩn nốt rễ lên nhanh (Sinorhizobium fredii) và một dòng vi khuẩn Pseudomonas spp. cùng được nghiên cứu sự tác động tích cực trên lúa cao sản (Oryza sativa L., giống MTL-250) trồng trên đất phù sa Cần Thơ trong 2 vụ liên tiếp (Đông Xuân 2003-
Cao Ngọc Điệp
core +1 more source
Advanced Science, EarlyView.A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du +17 more
wiley +1 more source
Wide‐Range Adaptive Metal Oxide for Hydrogen Sulfide Detection From Earth to Space‐Like Environments
Advanced Science, EarlyView.This work presents a gas sensing platform based on Cu‐doped SnO2 microspheres that operates reliably from ambient to space‐like conditions. The sensor maintains performance across vacuum and cryogenic environments, bypassing traditional oxygen‐mediated mechanisms, utilizing direct chemisorption and interfacial charge transfer.
Xi Chen +9 more
wiley +1 more source
Initial micropropagation strawberryFragaria annaninaL. from seed [PDF]
, 2017 In this study, we propagate shoots ofFragaria ananassa L.in vitrofrom seed by some kinds of cytokinin including BA (0.2-1.2 mg/L) or 2-ip (0.2-1.2 mg/L) or kinetin (0.2-1.2 mg/L). After 4 weeks, shoots are changed into root
Bùi Thị Thu Hằng +1 more
core +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
KHẢO SÁT ẢNH HƯỞNG CỦA CAO CHIẾT CÂY NHÀU (MORINDA CITRIFOLIA L.) ĐẾN HOẠT ĐỘNG CỦA ENZYME GLUCOSE-6-PHOSPHATASE Ở CHUỘT BỆNH TIỂU ĐƯỜNG [PDF]
, 2013 Bệnh tiểu đường (BTĐ) là bệnh do rối loạn chuyển hóa carbohydrate với đặc trưng là tăng glucose mãn tính. Tình trạng tăng đường máu mãn tính chịu chi phối của nhiều nguyên nhân khác nhau.
Bùi Tấn Anh +4 more
core +1 more source
Machine Learning for Green Solvents: Assessment, Selection and Substitution
Advanced Science, EarlyView.Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta +4 more
wiley +1 more source
Advanced Science, EarlyView.Poly[2‐(methacryloyloxy)ethyl]dimethyl‐(3‐sulfopropyl)ammonium hydroxide‐based organohydrogels are formed via nonsolvent‐induced gelation, featuring tunable viscoelasticity. Functional fillers (MXene nanosheets, magnetic NdFeB microparticles) enable electrical, magnetic, and mechanical responsiveness for applications in mechano‐tunable electromagnetic ...
Ziyue Miao +4 more
wiley +1 more source