Results 341 to 350 of about 244,605 (365)

Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function and Localization

2014
Effector proteins interact with GTPases in their active/GTP-bound state. To achieve this specificity, all effector proteins interact with Rab proteins via a similar Rab surface area which shows the largest conformational changes upon nucleotide exchange. This surface is also involved in the interaction with other Rab interacting proteins.
Oesterlin, Lena Katharina, Pylypenko, Olena, Goud, Bruno   +2 more
openaire   +4 more sources

[5] Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins

1995
Publisher Summary This chapter describes techniques for the expression and purification of Rab geranylgeranyltransferase (GGTase) and Rab escort protein (REP) in insect Spodoptera frugiperda (Sf9) cells using a baculovirus expression system that allows the production of milligram quantities of active components for the prenylation of Rab proteins ...
Miguel C. Seabra, Joseph L. Goldstein, Michael S. Brown, Scott A. Armstrong   +3 more
openaire   +3 more sources

Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface

Biochemical and Biophysical Research Communications, 2003
Rab proteins are a large family of monomeric GTPases with 60 members identified in the human genome. Rab GTPases require an isoprenyl modification to their C-terminus for membrane association and function in the regulation of vesicular trafficking pathways.
Richard F. Godfrey, José B. Pereira-Leal, Molly Strom, Miguel C. Seabra   +3 more
openaire   +3 more sources

Rab proteins in regulated exocytosis

Trends in Biochemical Sciences, 1994
Regulated exocytosis is responsible for neuronal communication, hormone secretion, food digestion, control of glucose uptake and many other basic processes. Despite the structural and functional diversity of the cells undergoing regulated exocytosis, all regulated exocytosis involves specialized vesicles that are stored in the cytoplasm and fuse with ...
Fischer von Mollard, Gabriele, STAHL, B, LI, C, SUDHOF, TC, JAHN, R   +4 more
openaire   +3 more sources

On the Disintegration of RaB

Journal of the Physical Society of Japan, 1953
The disintegration of RaB was studied by a β-ray spectrometer, with coincidence counter techniques. The β-ray spectrum of RaB obtained was complex, consisting of two components with end point energies 590±10 and 650±10 Kev. This results was also confirmed by coincidence measurements between the internal conversion electrons of the 242, 295 and 350 Kev ...
openaire   +2 more sources

Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTPases in Arabidopsis.

The Plant Journal, 2019
The Transport Protein Particle II (TRAPPII) is essential for exocytosis, endocytosis, protein sorting and cytokinesis. In spite of a considerable understanding of its biological role, little is known about Arabidopsis TRAPPII complex topology and ...
M. Kalde, Liam Elliott, Raksha Ravikumar, Katarzyna Rybak, Melina Altmann, Susan Klaeger, C. Wiese, Miriam Abele, Benjamin Al, Nils Kalbfuß, Xingyun Qi, Alexander Steiner, C. Meng, Huanquan Zheng, B. Kuster, Pascal Falter-Braun, C. Ludwig, I. Moore, F. Assaad   +18 more
semanticscholar   +1 more source

RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions

Neuroscience & Biobehavioral Reviews, 2014
A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role
Patrizia D’Adamo, Michela Masetti, Veronica Bianchi, Lorenzo Morè, Maria Lidia Mignogna, Maila Giannandrea, Silvia Gatti   +6 more
openaire   +3 more sources

Cycling of Rab Proteins: Role of Rab GDI in the Reversible Membrane Association of Rab GTP-Ases

1995
Small GTPases of the Rab family are specific regulators of intracellular vesicular traffic. Mutational analysis of Rab proteins suggests that it is the membrane-bound and GTP-bound form of the molecule that is active in vesicle docking or fusion. Since Rab proteins are also present in a cytosolic pool in the cell, it has been postulated that they ...
Marino Zerial, Oliver Ullrich
openaire   +2 more sources

Rab-H1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana.

Journal of Integrative Plant Biology, 2018
Cell-wall deposition of cellulose microfibrils is essential for plant growth and development. In plant cells, cellulose synthesis is accomplished by cellulose synthase complexes located in the plasma membrane.
Ming He, Miaochuan Lan, Baocai Zhang, Yihua Zhou, Youqun Wang, Lei Zhu, M. Yuan, Ying Fu   +7 more
semanticscholar   +1 more source

Rab GTPases as coordinators of vesicle traffic

Nature reviews. Molecular cell biology, 2009
H. Stenmark
semanticscholar   +1 more source