NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Anomalous Network Traffic Detection Method Based on an Elevated Harris Hawks Optimization Method and Gated Recurrent Unit Classifier. [PDF]
Sensors (Basel), 2022 Xiao Y, Kang C, Yu H, Fan T, Zhang H.
europepmc +1 more source
Word Lists for Interscholastic League Spelling Contests [PDF]
, 1939 University of Texas at Austin
core +2 more sources
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Single Neuronal Dynamical System in Self-Feedbacked Hopfield Networks and Its Application in Image Encryption. [PDF]
Entropy (Basel), 2021 Xu X, Chen S.
europepmc +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
Large heterozygous deletion and uniparental disomy masquerading as homozygosity in CHKB gene. [PDF]
Mol Genet Genomic Med, 2023 Wu T +5 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
Lightweight Digital Certificate Management and Efficacious Symmetric Cryptographic Mechanism over Industrial Internet of Things. [PDF]
Sensors (Basel), 2021 Ahmed AA.
europepmc +1 more source
New doubts on the importance of the logographic stage [PDF]
, 1996 International audienceThe objective of this longitudinal study was to evaluate reading strategies used by French children. A group of prereaders (N=37) was followed from the beginning of kindergarten to the end of the first grade.
Bonnet, Philippe +1 more
core +1 more source