Results 161 to 170 of about 2,701 (236)

TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang   +9 more
wiley   +1 more source

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

open access: yesAdvanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin   +19 more
wiley   +1 more source

Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway. [PDF]

open access: yesPLoS One, 2017
Liu H   +9 more
europepmc   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

open access: yesAdvanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun   +13 more
wiley   +1 more source

A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53. [PDF]

open access: yesCancer Res, 2018
Mao C   +19 more
europepmc   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

open access: yesAdvanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin   +15 more
wiley   +1 more source

Embedding permanent watermarks in synthetic genes. [PDF]

open access: yesPLoS One, 2012
Liss M   +6 more
europepmc   +1 more source

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