Results 161 to 170 of about 5,330,187 (273)

Quercetin and Cardiovascular Health: An Evidence‐Based Review of Risk Factors and Treatments

open access: yesFood Science &Nutrition, Volume 14, Issue 11, November 2026.
Quercetin is a naturally occurring polyphenolic phytochemical distributed in fruits and vegetables. Quercetin, as a flavonoid, showed significant antioxidant capabilities and potential therapeutic effects on CVD risk factors. Quercetin reduces cardiac hypertrophy and apoptosis in cardiomyocytes by modulating critical signaling pathways.
Mohammad Reza Khazdair   +2 more
wiley   +1 more source

Ursodeoxycholic Acid Confers Neuroprotection in Rats With Acute Cervical SCI and Attenuates NLRP3/Caspase‐1/GSDMD Pyroptotic Signaling

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Ursodeoxycholic Acid could inhibit activation of the NLRP3/Caspase‐1/GSDMD pyroptosis pathway and reduce the release of downstream inflammatory cytokines IL‐18 and IL‐1β in rats with acute C5 cervical SCI. This modulation is associated with attenuated secondary injury and improved functional outcomes.
Honghu Song   +10 more
wiley   +1 more source

Effects of Intubation Duration on Trachea: A Histopathological Study

open access: yesThe Laryngoscope, Volume 136, Issue 11, Page 4858-4865, November 2026.
This study evaluated the histopathological effects of prolonged endotracheal intubation on the human trachea using biopsy specimens obtained during tracheotomy. Prolonged intubation was associated with progressive inflammatory and structural changes, with tracheal dilatation and perichondritis increasing significantly after 14 days.
Osman Kilic   +6 more
wiley   +1 more source

Safety, Pharmacokinetics, and Efficacy Study of Porcine and Rabbit Antithymocyte Globulin in the Treatment of Patients With Severe Aplastic Anemia: A Multicenter, Prospective, Randomized, Open‐Label Clinical Trial

open access: yesMedComm, Volume 7, Issue 11, November 2026.
This prospective trial compared porcine‐ATG and rabbit‐ATG for severe aplastic anemia. Both agents peaked on Day 5, with faster clearance for rabbit‐ATG. Porcine‐ATG induced an early stable neutrophil rise, whereas rabbit‐ATG caused an initial neutrophil drop.
Yawen Zhang   +4 more
wiley   +1 more source

YAP Fuels Cerebral Cavernous Malformations by Regulating KLF4 Transcriptional Activity and Protein Stability

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Cerebral cavernous malformation (CCM) gene complex deficiency dual‐regulates YAP activity via a “dual‐pronged” mechanism: relieving LATS‐mediated inhibition to license YAP nuclear translocation, and promoting MAP3K3‐mediated YAP phosphorylation to stabilize YAP–KLF4 association.
Tingting Ye   +11 more
wiley   +1 more source

Unilateral Pulmonary Artery Lesion in an Immunocompromised Patient. [PDF]

open access: yesRespirol Case Rep
We report a case of a unilateral septic pulmonary artery thrombus presenting as pulmonary infarction and pulmonary hypertension in an immunocompromised host. ABSTRACT We report a 62‐year‐old man with myelodysplastic syndrome on immunosuppressive therapy who presented with right lung consolidation and neutropenia. Despite broad antimicrobial therapy for
Lee S   +7 more
europepmc   +2 more sources

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

open access: yesMedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou   +9 more
wiley   +1 more source

In Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
Short‐term cyclic partial reprogramming with Yamanaka factors protects aged mice from ischemic brain injury, preserving cognitive function, myelin integrity, and neuronal density, supporting partial reprogramming as a promising neuroprotective intervention in aging.
Paula R. Mallavibarrena   +5 more
wiley   +1 more source

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