Results 131 to 140 of about 34,636 (236)
Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]
, 2009 Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena +12 more
core
Gene Therapy for Cardiovascular Disease [PDF]
, 2003 The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H. +3 more
core +4 more sources
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
Presence of Myxoma Virus and Rabbit Hemorrhagic Disease Virus in Sylvilagus andinus in the Antisana Hydrological Conservation Area [PDF]
, 2021 Sylvilagus andinus (Andean rabbit) is one of the native mammal species most commonly seen in the Antisana Hydrological Conservation Area, east of Quito, Ecuador, and its population influences the ecological stability of the Andean moorlands.
Guzmán Arias, Cristian Aymar
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Aging Cell, Volume 24, Issue 6, June 2025.The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai +7 more
wiley +1 more source
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]
, 2003 Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, Amanda +5 more
core +3 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Microglia exhibit distinct transcriptional and morphological heterogeneity in experimental cerebral malaria (ECM) compared to physiological microglia. A unique subtype of ECM‐associated microglia, characterized by CXCL10highTNFαhighKi67+, mediates the recruitment and sustained activation of CD8+ T cells through ongoing interactions, exacerbating ...
Yi Wang +13 more
wiley +1 more source
A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8+ T-cell responses [PDF]
, 2004 We established a viral persistence model that involves the adoptive transfer of spleen cells from immunocompetent mice (H-2d) into Hantaan virus (HTNV)-infected severe combined immunodeficient (SCID, H-2d) mice.
Beck, R. +16 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.5‐HT7R deficiency can inhibit the abnormal changes of cAMP/PKA/MAPK signaling pathway and p53/xCT/GPX4 signaling pathway‐mediated ferroptosis caused by ADP‐hep in neuronal and M2 microglia, inhibit the inflammatory microenvironment, and promote neuronal survival, thereby improving cognitive dysfunction.
Xiao Zou +10 more
wiley +1 more source
VacciMonitorRabbit hemorrhagic disease virus 2 and Clostridium perfringens type A cause infections in rabbit. Vaccines are considered an effective strategy for fighting these infections.
Mahmoud M. Abotaleb +6 more
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