Results 101 to 110 of about 990,219 (302)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Identification of H1N2 influenza viruses in turkeys after spillover from swine and in vitro characterization

Virus Research
Influenza A viruses (IAVs) circulate among animals and humans and can cross species barriers to adapt to new hosts. In France, since 2020, a new genotype named H1avN2#E has predominated in pig farms.
Chloé Chavoix, Pascale Massin, François-Xavier Briand, Katell Louboutin, Rachel Busson, Florent Souchaud, Gautier Richard, Claire Martenot, Aurélie Le Roux, Edouard Hirchaud, Yannick Blanchard, Sophie Le Bouquin-Leneveu, Axelle Scoizec, Céline Deblanc, Séverine Hervé, Audrey Schmitz, Eric Niqueux, Gaëlle Simon, Ronan Le Goffic, Béatrice Grasland   +19 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Balanoposthitis, dyspareunia, and Treponema in the critically endangered Gilbert's potoroo (Potorous gilbertii) [PDF]

, 2011
The Gilbert's potoroo (Potorous gilbertii) is one of Australia's most critically endangered mammals with a current estimated population of 70 individuals.
Warren, K., Fenwick, S., Robertson, I., Friend, J.A., Vaughan-Higgins, R.J., Monaghan, C., Buller, N.   +6 more
core   +1 more source

Reliability of Palpation using three-dimensional keel bone models

Journal of Applied Poultry Research
Summary: Keel bone damage (KBD), including both deviations and fractures, is an important and wide-spread animal welfare problem of laying hens especially in non-cage housing systems.
E. Çavuşoğlu, M.J. Toscano, S.G. Gebhardt-Henrich   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nutritional digestive disturbances in weaner rabbits [PDF]

, 2012
Weaning is considered a stressful period for rabbits caused by abrupt changes of diet and environment. An immature immune system together with a transient decrease of nutrient digestibility places the animal in adverse conditions where digestive ...
Menoyo, David, García-Alonso, Javier, García-Rebollar, P., García Ruiz, Ana Isabel, Chamorro Francisco, Susana, Carabaño, Rosa, Nicodemus, Nuria, García Alonso, Javier, Nicodemus, N., Blas, J. C. de, Chamorro, Susana, García Rebollar, Pilar, Carabaño, R., Gómez Conde, Maria Soledad, De Blas, Carlos, Romero, Carlos, Gómez-Conde, M. S., Menoyo, D., García-Ruiz, A. I., Romero, Carmen   +19 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Should the 40-year-old practice of releasing virulent myxoma virus to control rabbits (Oryctolagus cuniculus) be continued? [PDF]

, 2006
Release of virulent myxoma virus has been a key component of rabbit-control operations in Queensland, Australia, since the 1960s but its use rests on anecdotal reports.
Gonzalez, T., van Leeuwen, B.H., Stagg, R., van Leeuwen, B. H., Kerr, P. J., Berman, D., Kerr, P.J.   +6 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source