Results 1 to 10 of about 985,336 (268)

Preliminary Results of Universiti Sultan Zainal Abidin Community Bone Health Screening in Manir, Kuala Terengganu using Bone Densitometry Calcaneal Quantitative Ultrasound (QUS) in Conjunction with Clinical Risk Factors [PDF]

Malaysian Orthopaedic Journal, 2023
I am writing to bring attention to the issue of fragility fractures in the growing aged population of Malaysia. According to the International Osteoporosis Foundation, up to 70% of people are at risk and underdiagnosed with osteoporosis.
Kamudin NAF, Ibrahim MS, Mohamed-Yusoff H   +2 more
doaj   +1 more source

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity

Cell Death and Disease, 2022
Aggrecan is a critical component of the extracellular matrix of all cartilages. One of the early hallmarks of osteoarthritis (OA) is the loss of aggrecan from articular cartilage followed by degeneration of the tissue.
Roman J. Krawetz, Yiru Elizabeth Wu, Karri L. Bertram, Anchita Shonak, Anand O. Masson, Guomin Ren, Catherine Leonard, Mohit Kapoor, John R. Matyas, Paul T. Salo   +9 more
doaj   +1 more source

Consensus for a primary care clinical decision-making tool for assessing, diagnosing, and managing shoulder pain in Alberta, Canada

BMC Family Practice, 2021
Background Shoulder pain is a highly prevalent condition and a significant cause of morbidity and functional disability. Current data suggests that many patients presenting with shoulder pain at the primary care level are not receiving high quality care.
Breda H. F. Eubank, Sebastian W. Lackey, Mel Slomp, Jason R. Werle, Colleen Kuntze, David M. Sheps   +5 more
doaj   +1 more source

Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury

Scientific Reports, 2023
Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment methods.
Leah Ferrie, Priyatha Premnath, Alexandra Olsen, Leila Larijani, Bryce A. Besler, Derrick E. Rancourt, Neil A. Duncan, T. Michael Underhill, Roman J. Krawetz   +8 more
doaj   +1 more source

Characterization of miR-335-5p and miR-335-3p in human osteoarthritic tissues

Arthritis Research & Therapy, 2023
Objective We aimed to characterize the expression patterns, gene targets, and functional effects of miR-335-5p and miR-335-3p among seven primary human knee and hip osteoarthritic tissue types.
Thomas G. Wilson, Madhu Baghel, Navdeep Kaur, Vasilios Moutzouros, Jason Davis, Shabana Amanda Ali   +5 more
doaj   +1 more source

Mesenchymal progenitor cells from non-inflamed versus inflamed synovium post-ACL injury present with distinct phenotypes and cartilage regeneration capacity

Stem Cell Research & Therapy, 2023
Background Osteoarthritis (OA) is a chronic debilitating disease impacting a significant percentage of the global population. While there are numerous surgical and non-invasive interventions that can postpone joint replacement, there are no current ...
Roman J. Krawetz, Leila Larijani, Jessica May Corpuz, Nicoletta Ninkovic, Nabangshu Das, Alexandra Olsen, Nicholas Mohtadi, Alexander Rezansoff, Antoine Dufour   +8 more
doaj   +1 more source

Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration

npj Regenerative Medicine, 2022
The wound healing response is one of most primitive and conserved physiological responses in the animal kingdom, as restoring tissue integrity/homeostasis can be the difference between life and death.
Roman J. Krawetz, Saleem Abubacker, Catherine Leonard, Anand O. Masson, Sophia Shah, Nadia Narendran, Pankaj Tailor, Suresh C. Regmi, Elodie Labit, Nicoletta Ninkovic, Jessica May Corpuz, Kenichi Ito, T. Michael Underhill, Paul T. Salo, Tannin A. Schmidt, Jeff A. Biernaskie   +15 more
doaj   +1 more source

In Vivo Static Retraction and Dynamic Elongation of Rotator Cuff Repair Tissue After Surgical Repair: A Preliminary Analysis at 3 Months

Orthopaedic Journal of Sports Medicine, 2022
Background: Rotator cuff repair is a common orthopaedic procedure that provides pain relief for many patients, but unfortunately, an estimated 20% to 70% of repair procedures will fail.
Rebekah L. Lawrence PT, PhD, Matthew C. Ruder MS, Roger Zauel MS, Alena Jalics BS, Adam M. Olszewski BS, Brian J. Diefenbach MS, Vasilios Moutzouros MD, Eric C. Makhni MD, Stephanie Muh MD, Michael J. Bey PhD   +9 more
doaj   +1 more source

Synovial fluid mesenchymal progenitor cells from patients with juvenile idiopathic arthritis demonstrate limited self-renewal and chondrogenesis

Scientific Reports, 2022
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases affecting joints with a prevalence of one in a thousand children.
Roman J. Krawetz, Asmaa Affan, Catherine Leonard, Dwaraka Natha Veeramreddy, Akash Fichadiya, Liam Martin, Heinrike Schmeling   +6 more
doaj   +1 more source

Thou Shalt not Fuse: Implant Survival Outcomes and Complications Following Arthroplasty in Hallux Rigidus [PDF]

Journal of Foot and Ankle Surgery (Asia Pacific), 2023
Aims and background: Hallux rigidus (HR) is a condition characterized by pain and loss of range of motion of the metatarsophalangeal joint (MTPJ) of the great toe caused by degenerative arthritis.
Freideriki Poutoglidou, Isabella Drummond, Joon Ha, Amit Patel, Francesc Malagelada, Lee Parker, Luckshmana Jeyaseelan   +6 more
doaj   +1 more source