Results 21 to 30 of about 985,336 (268)

The Influence of Supplemental Dietary Linoleic Acid on Skeletal Muscle Contractile Function in a Rodent Model of Barth Syndrome

Frontiers in Physiology, 2021
Barth syndrome is a rare and incurable X-linked (male-specific) genetic disease that affects the protein tafazzin (Taz). Taz is an important enzyme responsible for synthesizing biologically relevant cardiolipin (for heart and skeletal muscle, cardiolipin
Mario Elkes, Martin Andonovski, Daislyn Vidal, Madison Farago, Ryan Modafferi, Steven M. Claypool, Paul J. LeBlanc   +6 more
doaj   +1 more source

Assessing disease experience across the life span for individuals with osteogenesis imperfecta: challenges and opportunities for patient-reported outcomes (PROs) measurement: a pilot study

Orphanet Journal of Rare Diseases, 2019
Background Patient reported outcome (PRO) information is crucial for establishing better patient-provider communication, improving shared decision-making between clinicians and patients, assessing patient responses to therapeutic interventions, and ...
Laura L. Tosi, Marianne K. Floor, Christina M. Dollar, Austin P. Gillies, Members of the Brittle Bone Disease Consortium, Tracy S. Hart, David D. Cuthbertson, V. Reid Sutton, Jeffrey P. Krischer   +8 more
doaj   +1 more source

Adolescent Bone Health [PDF]

Archives of Pediatrics & Adolescent Medicine, 2006
Pediatric and adolescent care professionals have increasingly recognized the importance of understanding the skeletal health of their patients. Peak bone mass, the "bone bank" on which an individual will draw for their entire adult life, is likely achieved by late adolescence, with the critical window for accumulation occurring much earlier.
Keith J, Loud, Catherine M, Gordon
openaire   +2 more sources

Micro-CT Analysis of Spine Architecture in a Mouse Model of Scoliosis

Frontiers in Endocrinology, 2015
Objective: Mice homozygous for targeted deletion of the gene encoding fibroblast growth factor receptor 3 (FGFR3-/-) develop kyphoscoliosis by two months of age.
Chan eGao, Chan eGao, Brian P Chen, Brian P Chen, Michael B Sullivan, Michael B Sullivan, Jasmine eHui, Jasmine eHui, Jean eOuellet, Janet E Henderson, Janet E Henderson, Janet E Henderson, Neil eSaran   +12 more
doaj   +1 more source

Primary hyperparathyroidism presenting as atraumatic bilateral hip fractures: a case report

Journal of Medical Case Reports
Background Primary hyperparathyroidism (PHPT) affects up to 1.5% of older adults, causes bone loss at cortical sites and increases fracture risk. However, atraumatic hip fractures due to PHPT are rare. We report the case of an older female diagnosed with
Kevin McCarroll, Aisling Carroll, Finlay Brennan, Daire Gargan, Donal Fitzpatrick, Rosaleen Lannon   +5 more
doaj   +1 more source

p21−/− mice exhibit enhanced bone regeneration after injury

BMC Musculoskeletal Disorders, 2017
Background p21(WAF1/CIP1/SDI1), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair.
Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz   +7 more
doaj   +1 more source

Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide

BMC Cell Biology, 2017
Background Self-renewal and differentiation of embryonic stem cells (ESCs) is directed by biological and/or physical cues that regulate multiple signaling cascades. We have previously shown that mESCs seeded in a type I collagen matrix demonstrate a loss
Olesja Hazenbiller, Neil A. Duncan, Roman J. Krawetz   +2 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Tenofovir and bone health [PDF]

Current Opinion in HIV and AIDS, 2016
With continued improvements to the antiviral efficacy and tolerability of antiretroviral therapy, long-term safety of antiretroviral therapy has become paramount. Low bone mineral density and fragility fractures are more common in HIV-infected individuals than in the general population.
Philip M, Grant, Aoife G, Cotter
openaire   +2 more sources

Ewing Sarcoma in Infants and Children Under 2 Years of Age: A French Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ewing sarcoma, the second most common primary bone cancer in children, requires intensive treatment that may lead to significant long‐term sequelae, particularly in infants. We retrospectively analyzed data from 1621 French patients treated between 1988 and 2015 within the EW88/93/97 or EE99 trials, focusing on 17 infants diagnosed before 24 ...
Elodie Verdier, Nathalie Cozic, Marie‐Dominique Tabone, Gaelle Pierron, Perrine Marec‐Berard, Sarah Winter, Gabriel Revon‐Rivière, Cyril Lervat, Dominique Plantaz, Marie‐Pierre Castex, Gregory Guimard, Estelle Thebaud, Stephanie Proust, Laure Saumet, Natacha Entz‐Werle, Sophie Taque, Cécile Vérité, Marta Jimenez, Nathalie Gaspar   +18 more
wiley   +1 more source