Results 21 to 30 of about 13,986,186 (309)

An effective treatment in Erdheim Chester disease: vemurafenib: a case report

Journal of Medical Case Reports, 2023
Background Erdheim Chester disease (ECD) is a rare disease with multisystemic involvement in the group of non-langerhans cell histiocytosis. Although nearly 100 years have passed since its definition, the number of cases reported all over the world is ...
Ersin Bozan, Tahir Darçın, Samet Yaman, Tuğçe Nur Yiğenoğlu, Merih Kızıl Çakar, Mehmet Sinan Dal, Fevzi Altuntaş   +6 more
doaj   +1 more source

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of the bone) : a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventative treatment if they were available [PDF]

, 2008
Background: Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
Ralston, Stuart H., Charnock Keith, Campbell, MK, Graeme MacLennan, John Weinman, McCallum Marilyn, Robertson, C., Weinman, John, Miedzybrodska Zosia, Langston Anne L, Weinman John, Vikki A Entwistle, Campbell, Marion K, McCallum, M., Robertson Clare, Entwistle, V.A, Campbell, Marion K., Francis, J., Charnock, K., Ralston, Stuart H, Langston, A. L., Robertson, Clare, MacLennan, Graeme Stewart, Entwistle Vikki A, Campbell, M K, Langston, AL, Francis, Jillian Joy, Marteau Theresa, Zosia Miedzybrodska, Miedzybrodska, Z, Langston, Anne L, Entwistle, Vikki A., Marilyn McCallum, Langston, A L, Entwistle, Vikki, Ralston, SH, Campbell, Marion Kay, Anne L Langston, Jill Francis, Ralston, S H, Miedzybrodzka, Zosia, Marie Johnston, Charnock, Keith, Francis, Jill, Weinman, J, Ralston, S.H, Weinman, J., Langston, A.L, Robertson, C, Entwistle, V A, Clare Robertson, McCallum, Marilyn, Ralston, S., Johnston Marie, Marteau, T, Campbell Marion K, Miedzybrodzka, Z., Entwistle, Vikki A, Campbell, M.K, Theresa Marteau, Johnston, M, Stuart H Ralston, Langston, Anne L., Entwistle, V., Johnston, M., Francis Jill, Ralston Stuart H, MacLennan, G, Campbell, M. K., Marteau, T., Entwistle, VA, Johnston, Marie, Marion K Campbell, Maclennan, Graeme, Miedzybrodska, Zosia, McCallum, M, MacLennan Graeme, Keith Charnock, Francis, J, Charnock, K, Marteau, Theresa, MacLennan, G.   +81 more
core   +2 more sources

Third BNT162b2 mRNA SARS-CoV-2 Vaccine Dose Significantly Enhances Immunogenicity in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation

Vaccines, 2023
COVID-19-related mortality among hematopoietic stem cell transplantation (HSCT) recipients in the pre-vaccine era ranged between 22 and 33%. The Pfizer/BioNTech BNT162b2 vaccine demonstrated significant immunogenicity and efficacy in the healthy ...
Israel Henig, Jonathan Isenberg, Dana Yehudai-Ofir, Ronit Leiba, Shimrit Ringelstein-Harlev, Ron Ram, Batia Avni, Odelia Amit, Sigal Grisariu, Tehila Azoulay, Ilana Slouzkey, Tsila Zuckerman   +11 more
doaj   +1 more source

Multilevel instrumented posterolateral lumbar spine fusion with an allogeneic cellular bone graft

Journal of Orthopaedic Surgery and Research, 2019
Background Low back pain (LBP) is the leading cause of absence from work, disability, and impaired quality of life. Fusion surgery may be indicated when non-operative treatments have failed to provide relief.
John F. Hall, Julie B. McLean, Savannah M. Jones, Mark A. Moore, Michelle D. Nicholson, Kimberly A. Dorsch   +5 more
doaj   +1 more source

The toxic effects of chloroquine and hydroxychloroquine on skeletal muscle: a systematic review and meta-analysis

Scientific Reports, 2021
The aim of this systematic review was to perform qualitative and quantitative analysis on the toxic effects of chloroquine (CQ) and hydroxychloroquine (HCQ) on skeletal muscles. We designed the study according to PRISMA guidelines.
Claudia Cristina Biguetti, Joel Ferreira Santiago Junior, Matthew William Fiedler, Mauro Toledo Marrelli, Marco Brotto   +4 more
doaj   +1 more source

The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

Arthritis Research & Therapy, 2020
Background Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes have been reported in OA synovium ...
Cindy C. Shu, Sanaa Zaki, Varshini Ravi, Antonella Schiavinato, Margaret M. Smith, Christopher B. Little   +5 more
doaj   +1 more source

Protocol for the United Kingdom Rotator Cuff Study (UKUFF) : a randomised controlled trial of open and arthroscopic rotator cuff repair [PDF]

, 2014
This project was funded by the NIHR Health Technology Assessment programme (project number 05/47/02). J. L. Rees has received a grant from Oxford University which is related to this paper. J.
Cooper, C. D., Bruhn, H., Beard, D. J., Carr, A. J., Ramsay, C. R., Dawson, J., Moser, J., Campbell, M. K., Fitzpatrick, R., Gray, A., Rees, J. L.   +10 more
core   +1 more source

Antiepileptics and bone health [PDF]

Therapeutic Advances in Musculoskeletal Disease, 2011
In recent years there has been increasing evidence suggesting that epilepsy and its treatment can have adverse effects on bone mineralization and calcium metabolism. Many studies have shown a significant reduction in bone mineral density (BMD) and an increased fracture risk in patients treated with enzyme-inducing antiepileptics (phenobarbital ...
Christian, Meier, Marius E, Kraenzlin
openaire   +2 more sources

The Influence of Supplemental Dietary Linoleic Acid on Skeletal Muscle Contractile Function in a Rodent Model of Barth Syndrome

Frontiers in Physiology, 2021
Barth syndrome is a rare and incurable X-linked (male-specific) genetic disease that affects the protein tafazzin (Taz). Taz is an important enzyme responsible for synthesizing biologically relevant cardiolipin (for heart and skeletal muscle, cardiolipin
Mario Elkes, Martin Andonovski, Daislyn Vidal, Madison Farago, Ryan Modafferi, Steven M. Claypool, Paul J. LeBlanc   +6 more
doaj   +1 more source

Assessing disease experience across the life span for individuals with osteogenesis imperfecta: challenges and opportunities for patient-reported outcomes (PROs) measurement: a pilot study

Orphanet Journal of Rare Diseases, 2019
Background Patient reported outcome (PRO) information is crucial for establishing better patient-provider communication, improving shared decision-making between clinicians and patients, assessing patient responses to therapeutic interventions, and ...
Laura L. Tosi, Marianne K. Floor, Christina M. Dollar, Austin P. Gillies, Members of the Brittle Bone Disease Consortium, Tracy S. Hart, David D. Cuthbertson, V. Reid Sutton, Jeffrey P. Krischer   +8 more
doaj   +1 more source