Results 81 to 90 of about 102,798 (297)

Role of Oral Rabies Vaccines in the Elimination of Dog-Mediated Human Rabies Deaths

Emerging Infectious Diseases, 2020
Domestic dogs are responsible for nearly all the »59,000 global human rabies deaths that occur annually. Numerous control measures have been successful at eliminating dog-mediated human rabies deaths in upper-income countries, including dog population ...
R. Wallace, F. Cliquet, C. Fehlner-Gardiner, A. Fooks, C. Sabeta, Á. A. Setién, C. Tu, Vlad Vuta, B. Yakobson, Dong-Kun Yang, G. Brückner, C. Freuling, L. Knopf, A. Metlin, P. Pozzetti, P. P. Suseno, S. Shadomy, G. Torres, M. Vigilato, B. Abela-Ridder, T. Müller   +20 more
semanticscholar   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Viral Metagenomic Profiling of Croatian Bat Population Reveals Sample and Habitat Dependent Diversity

Viruses, 2020
To date, the microbiome, as well as the virome of the Croatian populations of bats, was unknown. Here, we present the results of the first viral metagenomic analysis of guano, feces and saliva (oral swabs) of seven bat species (Myotis myotis, Miniopterus
Ivana Šimić, Tomaž Mark Zorec, Ivana Lojkić, Nina Krešić, Mario Poljak, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Vida Zrnčić, Anđela Ćukušić, Tomislav Bedeković   +10 more
doaj   +1 more source

Ampliseq for Illumina Technology Enables Detailed Molecular Epidemiology of Rabies Lyssaviruses from Infected Formalin-Fixed Paraffin-Embedded Tissues

Viruses, 2022
Whole genome sequencing of rabies lyssaviruses (RABVs) has enabled the generation of highly detailed phylogenies that reveal viral transmission patterns of disease in reservoir species.
Susan Angela Nadin-Davis, Allison Hartke, Mingsong Kang   +2 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

What is rural? Examining the relationship between human populations and their inter-connectedness in the context of communicable disease transmission

International Journal of Health Geographics
Background Rurality and urbanicity are recognized determinants of public health outcomes that influence policy and resource allocation. However, many commonly used methods to classify the rural-urban continuum, such as the Rural-Urban Commuting Area ...
Cassandra Boutelle, Patrick Corbett, Andrew Gibson, Frederic Lohr, Catherine Swedberg, Jesse Blanton, Ryan Wallace   +6 more
doaj   +1 more source

Molecular and serological survey of lyssaviruses in Croatian bat populations

BMC Veterinary Research, 2018
Background Rabies is the only known zoonotic disease of bat origin in Europe. The disease is caused by species belonging to the genus Lyssavirus. Five Lyssavirus species, i.e., European bat lyssavirus (EBLV)-1, EBLV-2, Bokeloh bat lyssavirus, Lleida bat ...
Ivana Šimić, Ivana Lojkić, Nina Krešić, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Anđela Ćukušić, Vida Zrnčić, Tomislav Bedeković   +8 more
doaj   +1 more source

Serum Neutralisation profiles of Straw-Coloured Fruit Bats (Eidolon helvum) against four Lineages of Lagos Bat Lyssavirus

International Journal of Infectious Diseases, 2022
Purpose: Bats are the natural reservoir hosts for many viral zoonotic pathogens including lyssaviruses that can cause the fatal disease rabies. Lagos bat lyssavirus (LBV), a member of phylogroup II lyssaviruses, has been classified into four lineages (A,
V.O. Ameh, G. Wu, H. Goharriz, A. Fooks, C.T. Sabeta, L. Mcelhinney   +5 more
doaj   +1 more source

Rabies – epidemiology, pathogenesis, public health concerns and advances in diagnosis and control: a comprehensive review

Veterinary Quarterly, 2017
Rabies is a zoonotic, fatal and progressive neurological infection caused by rabies virus of the genus Lyssavirus and family Rhabdoviridae. It affects all warm-blooded animals and the disease is prevalent throughout the world and endemic in many ...
Rajendra Singh, K. Singh, S. Cherian, M. Saminathan, S. Kapoor, G. B. Manjunatha Reddy, S. Panda, K. Dhama   +7 more
semanticscholar   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source