Results 71 to 80 of about 102,798 (297)

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

open access: yesAdvanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong   +12 more
wiley   +1 more source

Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006–2018

open access: yesScientific Reports, 2020
Vaccinating dogs against rabies is an effective means of reducing human rabies. We subjected 1327 clinically diagnosed human rabies death and mass dog vaccination (MDV) data during 2006–2018 to quantify the impacts of MDV on human rabies incidence in ...
Sumon Ghosh   +18 more
semanticscholar   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang   +9 more
wiley   +1 more source

Domestic dog demographic structure and dynamics relevant to rabies control planning in urban areas in Africa: the case of Iringa, Tanzania [PDF]

open access: yes, 2012
<p>Background Mass vaccinations of domestic dogs have been shown to effectively control canine rabies and hence human exposure to rabies. Knowledge of dog population demography is essential for planning effective rabies vaccination programmes ...
Kazwala Rudovick R   +24 more
core   +3 more sources

Evaluation of a portable multiplex real-time pcr assay for the detection of monkeypox virus and non-variola orthopoxviruses

open access: yesVirology Journal
Monkeypox (mpox) is the most significant orthopoxvirus (OPXV) infection in humans since smallpox eradication. The World Health Organization (WHO) has twice declared public health emergency of international concern due to the expansive spread of clade I ...
Shanshan Li   +13 more
doaj   +1 more source

Review of rabies in Nepal

open access: yesOne Health, 2020
Rabies is a global problem, but the burden is higher in less developed or developing countries of Asia and Africa. In Nepal, rabies is reported to kill around 500 animals and up to 32 human beings in recent years, with possible under-reporting of cases ...
Saurav Pantha   +5 more
semanticscholar   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

open access: yesAdvanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du   +10 more
wiley   +1 more source

The epidemiology of rabies and canine distemper in the Serengeti, Tanzania. [PDF]

open access: yes
Rabies and canine distemper are fatal diseases of mammals and of concern in the Serengeti, Tanzania both for public health and wildlife conservation.
Cleaveland, Sarah
core   +1 more source

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P [PDF]

open access: yes, 1984
Cytolytic T lymphocyte precursors (CTL-P) were sensitized in vivo by intraplantar infection of C57BL/6 mice with a lethal dose of rabies virus, strain ERA (ERA).
Reddehase, M. J.   +6 more
core   +1 more source

Revealing the complexity of vampire bat rabies “spillover transmission”

open access: yesInfectious Diseases of Poverty, 2023
Background The term virus ‘spillover’ embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new, naïve yet susceptible and permissive host species.
Luis E. Escobar   +4 more
doaj   +1 more source

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