Results 1 to 10 of about 105,643 (212)

Oral Bait Immunization of Eurasian Wild Boar (Sus scrofa) Against African Swine Fever with “ASFV-G-ΔI177L”: Bait Performance, Immunogenicity, and Environmental Monitoring

Vaccines
Background/Objectives: African swine fever is currently the most devastating viral disease affecting domestic and wild suids, causing major economic losses and severe impacts on natural populations.
Jörg Beckmann, Sandra Blome, Nuria Bujan, Christian Gortázar, Theresa Holzum, Steffen Ortmann, David Relimpio, Alexander Schäfer, Elisenda Viaplana, Ad Vos, Virginia Friedrichs   +10 more
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A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

OncoImmunology, 2018
VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated Salmonella typhi carrying an expression plasmid encoding VEGFR2, an antigen expressed on tumor vasculature and a stable and accessible target for anti-angiogenic intervention.
Friedrich H. Schmitz-Winnenthal, Nicolas Hohmann, Thomas Schmidt, Lilli Podola, Tobias Friedrich, Heinz Lubenau, Marco Springer, Sébastien Wieckowski, Klaus M. Breiner, Gerd Mikus, Markus W. Büchler, Anne-Valerie Keller, Ruhan Koc, Christoph Springfeld, Phillip Knebel, Mariana Bucur, Lars Grenacher, Walter E. Haefeli, Philipp Beckhove   +18 more
doaj   +1 more source

Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs

Frontiers in Immunology, 2021
Many pathogens enter the host via the gut, causing disease in animals and humans. A robust intestinal immune response is necessary to protect the host from these gut pathogens. Despite being best suited for eliciting intestinal immunity, oral vaccination
Hans Van der Weken, Raquel Sanz Garcia, Niek N. Sanders, Eric Cox, Bert Devriendt   +4 more
doaj   +1 more source

In Vivo Safety Studies With SPBN GASGAS in the Frame of Oral Vaccination of Foxes and Raccoon Dogs Against Rabies

Frontiers in Veterinary Science, 2018
In order to obtain Marketing Authorization for an oral rabies vaccine in the European Union, not only safety studies in the target species, red fox and raccoon dog, are required.
Steffen Ortmann, Antje Kretzschmar, Christiane Kaiser, Thomas Lindner, Conrad Freuling, Christian Kaiser, Peter Schuster, Thomas Mueller, Ad Vos   +8 more
doaj   +1 more source

Comparative Efficacy of Parenteral and Mucosal Recombinant Probiotic Vaccines Against SARS-CoV-2 and S. pneumoniae Infections in Animal Models

Vaccines
Background: The accumulation of specific IgG antibodies in blood serum is considered a key criterion for the effectiveness of vaccination. For several vaccine-preventable infections, quantitative indicators of the humoral response have been established ...
Galina Leontieva, Tatiana Kramskaya, Tatiana Gupalova, Elena Bormotova, Yulia Desheva, Dmitry Korzhevsky, Olga Kirik, Irina Koroleva, Sergey Borisevitch, Alexander Suvorov   +9 more
doaj   +1 more source

Blocking Pathogen Transmission at the Source: Reservoir Targeted OspA-Based Vaccines Against Borrelia burgdorferi

Frontiers in Cellular and Infection Microbiology, 2014
Control strategies are especially challenging for microbial diseases caused by pathogens that persist in wildlife reservoirs and use arthropod vectors to cycle amongst those species. One of the most relevant illnesses that pose a direct human health risk
Maria eGomes-Solecki
doaj   +1 more source

Oral adverse events following COVID-19 and influenza vaccination in Australia

Human Vaccines & Immunotherapeutics, 2023
Vaccine hesitancy, spurred by misinterpretation of Adverse Events (AEs), threatens public health. Despite sporadic reports of oral AEs post-COVID-19 vaccination, systematic analysis is scarce.
Abanoub Riad, Julien Issa, Sameh Attia, Ladislav Dušek, Miloslav Klugar   +4 more
doaj   +1 more source

Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

Drug Delivery, 2023
Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease.
Ruifeng Mao, Jin Wang, Ying Xu, Yuqi Wang, Mengmeng Wu, Lixia Mao, Yingying Chen, Dengchao Li, Tong Zhang, Enjie Diao, Zhenjing Chi, Yefu Wang, Xin Chang   +12 more
doaj   +1 more source

Field Studies Evaluating Bait Acceptance and Handling by Free-Roaming Dogs in Thailand

Veterinary Sciences, 2018
(1) Background: As part of the ongoing endeavor to eliminate dog-mediated human rabies in Thailand, renewed interest has been shown in oral vaccination of dogs as a supplementary tool to increase vaccination coverage of the dog population.
Suwicha Kasemsuwan, Karoon Chanachai, Tanu Pinyopummintr, Kansuda Leelalapongsathon, Kitipat Sujit, Ad Vos   +5 more
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Humoral Immune Response of Thai Dogs after Oral Vaccination against Rabies with the SPBN GASGAS Vaccine Strain

Vaccines, 2020
Applied research is crucial in pushing the boundaries and finding a solution to the age-old problem of dog-mediated rabies. Although oral vaccination of dogs is considered to have great potential in mass dog vaccination campaigns and could have far ...
Kansuda Leelahapongsathon, Suwicha Kasemsuwan, Tanu Pinyopummintr, Orawan Boodde, Parinya Phawaphutayanchai, Nirut Aiyara, Katharina Bobe, Ad Vos, Virginia Friedrichs, Thomas Müller, Conrad M. Freuling, Karoon Chanachai   +11 more
doaj   +1 more source