Results 31 to 40 of about 100,059 (161)

A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity

Frontiers in Immunology, 2022
An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain.
Bertrand Bellier, Alicia Saura, Alicia Saura, Lucas A. Luján, Lucas A. Luján, Cecilia R. Molina, Cecilia R. Molina, Hugo D. Luján, Hugo D. Luján, David Klatzmann, David Klatzmann   +10 more
doaj   +1 more source

Enzootic Rabies Elimination from Dogs and Reemergence in Wild Terrestrial Carnivores, United States

Emerging Infectious Diseases, 2008
To provide molecular and virologic evidence that domestic dog rabies is no longer enzootic to the United States and to identify putative relatives of dog-related rabies viruses (RVs) circulating in other carnivores, we studied RVs associated with recent ...
Andrés Velasco-Villa, Serena A. Reeder, Lillian A. Orciari, Pamela A. Yager, Richard Franka, Jesse D. Blanton, Letha Zuckero, Patrick Hunt, Ernest H. Oertli, Laura E. Robinson, Charles E. Rupprecht   +10 more
doaj   +1 more source

Basics of rabies prevention in the Republic of Belarus (review)

Ветеринария сегодня
Introduction. Rabies remains one of the most dangerous zoonotic diseases. The Republic of Belarus is affected by animal rabies and the disease is reported in all regions of the country.Objective.
I. A. Subotsina, S. V. Darovskych, A. L. Leshkevich, I. A. Dorofeychik, A. K. Lyakhovsky   +4 more
doaj   +1 more source

Oral Bait Immunization of Eurasian Wild Boar (Sus scrofa) Against African Swine Fever with “ASFV-G-ΔI177L”: Bait Performance, Immunogenicity, and Environmental Monitoring

Vaccines
Background/Objectives: African swine fever is currently the most devastating viral disease affecting domestic and wild suids, causing major economic losses and severe impacts on natural populations.
Jörg Beckmann, Sandra Blome, Nuria Bujan, Christian Gortázar, Theresa Holzum, Steffen Ortmann, David Relimpio, Alexander Schäfer, Elisenda Viaplana, Ad Vos, Virginia Friedrichs   +10 more
doaj   +1 more source

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

OncoImmunology, 2018
VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated Salmonella typhi carrying an expression plasmid encoding VEGFR2, an antigen expressed on tumor vasculature and a stable and accessible target for anti-angiogenic intervention.
Friedrich H. Schmitz-Winnenthal, Nicolas Hohmann, Thomas Schmidt, Lilli Podola, Tobias Friedrich, Heinz Lubenau, Marco Springer, Sébastien Wieckowski, Klaus M. Breiner, Gerd Mikus, Markus W. Büchler, Anne-Valerie Keller, Ruhan Koc, Christoph Springfeld, Phillip Knebel, Mariana Bucur, Lars Grenacher, Walter E. Haefeli, Philipp Beckhove   +18 more
doaj   +1 more source

Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs

Frontiers in Immunology, 2021
Many pathogens enter the host via the gut, causing disease in animals and humans. A robust intestinal immune response is necessary to protect the host from these gut pathogens. Despite being best suited for eliciting intestinal immunity, oral vaccination
Hans Van der Weken, Raquel Sanz Garcia, Niek N. Sanders, Eric Cox, Bert Devriendt   +4 more
doaj   +1 more source

Comparative Efficacy of Parenteral and Mucosal Recombinant Probiotic Vaccines Against SARS-CoV-2 and S. pneumoniae Infections in Animal Models

Vaccines
Background: The accumulation of specific IgG antibodies in blood serum is considered a key criterion for the effectiveness of vaccination. For several vaccine-preventable infections, quantitative indicators of the humoral response have been established ...
Galina Leontieva, Tatiana Kramskaya, Tatiana Gupalova, Elena Bormotova, Yulia Desheva, Dmitry Korzhevsky, Olga Kirik, Irina Koroleva, Sergey Borisevitch, Alexander Suvorov   +9 more
doaj   +1 more source

In Vivo Safety Studies With SPBN GASGAS in the Frame of Oral Vaccination of Foxes and Raccoon Dogs Against Rabies

Frontiers in Veterinary Science, 2018
In order to obtain Marketing Authorization for an oral rabies vaccine in the European Union, not only safety studies in the target species, red fox and raccoon dog, are required.
Steffen Ortmann, Antje Kretzschmar, Christiane Kaiser, Thomas Lindner, Conrad Freuling, Christian Kaiser, Peter Schuster, Thomas Mueller, Ad Vos   +8 more
doaj   +1 more source

Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

Drug Delivery, 2023
Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease.
Ruifeng Mao, Jin Wang, Ying Xu, Yuqi Wang, Mengmeng Wu, Lixia Mao, Yingying Chen, Dengchao Li, Tong Zhang, Enjie Diao, Zhenjing Chi, Yefu Wang, Xin Chang   +12 more
doaj   +1 more source

Blocking Pathogen Transmission at the Source: Reservoir Targeted OspA-Based Vaccines Against Borrelia burgdorferi

Frontiers in Cellular and Infection Microbiology, 2014
Control strategies are especially challenging for microbial diseases caused by pathogens that persist in wildlife reservoirs and use arthropod vectors to cycle amongst those species. One of the most relevant illnesses that pose a direct human health risk
Maria eGomes-Solecki
doaj   +1 more source