Results 51 to 60 of about 1,747,691 (292)

Gut mucosal immune responses and protective efficacy of oral yeast Cyprinid herpesvirus 2 (CyHV-2) vaccine in Carassius auratus gibelio

Frontiers in Immunology, 2022
Cyprinid herpesvirus 2 (CyHV-2) causes herpesviral hematopoietic necrosis (HVHN) disease outbreaks in farmed Cyprinid fish, which leads to serious economic losses worldwide.
Zhao-Ran Dong, Qing-Jiang Mu, Wei-Guang Kong, Da-Cheng Qin, Yong Zhou, Xin-You Wang, Gao-Feng Cheng, Yang-Zhi Luo, Tao-Shan Ai, Zhen Xu, Zhen Xu   +10 more
doaj   +1 more source

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Orally administered extracellular vesicles from Salmonella-infected macrophages confer protective immunity in vivo

Frontiers in Immunology
Salmonella is a leading cause of foodborne illness in the United States and worldwide. This enteric pathogen deploys various mechanisms to evade the intestinal mucosal barrier to enhance its survival and further infect systemic tissues.
Saloni Bhimani, Jorge J. Canas, Samantha M. Enslow, Ryan Mulcare, Mariola J. Ferraro, Mariola J. Ferraro   +5 more
doaj   +1 more source

A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity

Frontiers in Immunology, 2022
An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain.
Bertrand Bellier, Alicia Saura, Alicia Saura, Lucas A. Luján, Lucas A. Luján, Cecilia R. Molina, Cecilia R. Molina, Hugo D. Luján, Hugo D. Luján, David Klatzmann, David Klatzmann   +10 more
doaj   +1 more source

Enzootic Rabies Elimination from Dogs and Reemergence in Wild Terrestrial Carnivores, United States

Emerging Infectious Diseases, 2008
To provide molecular and virologic evidence that domestic dog rabies is no longer enzootic to the United States and to identify putative relatives of dog-related rabies viruses (RVs) circulating in other carnivores, we studied RVs associated with recent ...
Andrés Velasco-Villa, Serena A. Reeder, Lillian A. Orciari, Pamela A. Yager, Richard Franka, Jesse D. Blanton, Letha Zuckero, Patrick Hunt, Ernest H. Oertli, Laura E. Robinson, Charles E. Rupprecht   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Basics of rabies prevention in the Republic of Belarus (review)

Ветеринария сегодня
Introduction. Rabies remains one of the most dangerous zoonotic diseases. The Republic of Belarus is affected by animal rabies and the disease is reported in all regions of the country.Objective.
I. A. Subotsina, S. V. Darovskych, A. L. Leshkevich, I. A. Dorofeychik, A. K. Lyakhovsky   +4 more
doaj   +1 more source