Results 61 to 70 of about 1,747,691 (292)

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Oral Bait Immunization of Eurasian Wild Boar (Sus scrofa) Against African Swine Fever with “ASFV-G-ΔI177L”: Bait Performance, Immunogenicity, and Environmental Monitoring

Vaccines
Background/Objectives: African swine fever is currently the most devastating viral disease affecting domestic and wild suids, causing major economic losses and severe impacts on natural populations.
Jörg Beckmann, Sandra Blome, Nuria Bujan, Christian Gortázar, Theresa Holzum, Steffen Ortmann, David Relimpio, Alexander Schäfer, Elisenda Viaplana, Ad Vos, Virginia Friedrichs   +10 more
doaj   +1 more source

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

OncoImmunology, 2018
VXM01 is a first-in-kind orally applied tumor vaccine based on live attenuated Salmonella typhi carrying an expression plasmid encoding VEGFR2, an antigen expressed on tumor vasculature and a stable and accessible target for anti-angiogenic intervention.
Friedrich H. Schmitz-Winnenthal, Nicolas Hohmann, Thomas Schmidt, Lilli Podola, Tobias Friedrich, Heinz Lubenau, Marco Springer, Sébastien Wieckowski, Klaus M. Breiner, Gerd Mikus, Markus W. Büchler, Anne-Valerie Keller, Ruhan Koc, Christoph Springfeld, Phillip Knebel, Mariana Bucur, Lars Grenacher, Walter E. Haefeli, Philipp Beckhove   +18 more
doaj   +1 more source

Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs

Frontiers in Immunology, 2021
Many pathogens enter the host via the gut, causing disease in animals and humans. A robust intestinal immune response is necessary to protect the host from these gut pathogens. Despite being best suited for eliciting intestinal immunity, oral vaccination
Hans Van der Weken, Raquel Sanz Garcia, Niek N. Sanders, Eric Cox, Bert Devriendt   +4 more
doaj   +1 more source

BCG vaccination induces different cytokine profiles following infant BCG vaccination in the UK and Malawi [PDF]

, 2011
BACKGROUND: BCG vaccination of infants is thought to provide good protection in all settings. This study investigated whether Malawian infants made weaker responses across a cytokine panel after BCG vaccination, compared with UK infants.METHODS: Diluted ...
Hazel M. Dockrell, Newport, Melanie J, Mvula, Hazzie, Weir, Rosemary E., Rose Blitz, Fine, P.E., Steven G. Smith, Nuala McGrath (230042), Crampin, Amelia C, Keith Branson (239422), Hazel M Dockrell (10414616), Sian Floyd, Fine, Paul E, Crampin, Amelia C., Weir, R.E., McGrath, N., Floyd, Sian, Rose Blitz (356877), Newport, M.J., Anne Ben-Smith (244056), Melanie Newport (4461202), Lalor, Maeve K., Hazzie Mvula, Lalor, M.K., Maeve K Lalor (16181825), Sian Floyd (239400), Weir, Rosemary E, Lalor, Maeve K, Gorak-Stolinska, P., Fine, Paul E., Nuala McGrath, Crampin, A.C., Ben-Smith, A., Steven G Smith (16181831), Maeve K. Lalor, Hazzie Mvula (271278), Smith, S.G., Mvula, H., Smith, Steven G., Smith, Steven G, Patricia Gorak-Stolinska (356875), Floyd, S., Blitz, R., McGrath, Nuala, Amelia C. Crampin, Gorak-Stolinska, Patricia, Rosemary E. Weir, Branson, K., Amelia C Crampin (10281422), Ben-Smith, Anne, Dockrell, Hazel M., Paul E. Fine, Paul E Fine (16181834), Blitz, Rose, Dockrell, H.M., Rosemary E Weir (16181828), Keith Branson, Anne Ben-Smith, Dockrell, Hazel M, Newport, Melanie J., Branson, Keith, Patricia Gorak-Stolinska, Melanie J. Newport   +62 more
core   +1 more source

Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

Drug Delivery, 2023
Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease.
Ruifeng Mao, Jin Wang, Ying Xu, Yuqi Wang, Mengmeng Wu, Lixia Mao, Yingying Chen, Dengchao Li, Tong Zhang, Enjie Diao, Zhenjing Chi, Yefu Wang, Xin Chang   +12 more
doaj   +1 more source

Formulation technologies for oral vaccines [PDF]

Clinical and Experimental Immunology, 2019
SummaryMany options now exist for constructing oral vaccines which, in experimental systems, have shown themselves to be able to generate highly effective immunity against infectious diseases. Their suitability for implementation in clinical practice, however, for prevention of outbreaks, particularly in low- and middle-income countries (LMIC), is not ...
openaire   +4 more sources

Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses [PDF]

, 2007
Objective: To determine the cost effectiveness of strategies for preventing neonatal infection with group B streptococci and other bacteria in the UK and the value of further information from research.
Asseburg, C, Ades, A.E., Asseburg, C., Gilbert, RE, Claxton, Karl, Ades, A. E., Asseburg, Christian, Gilbert, R.E., Philips, Z., Gilbert, Ruth E., Welton, N.J., Colbourn, T.E., Claxton, K, Philips, Zoe, Bojke, L, Colbourn, TE, Welton, NJ, Welton, Nicky J., Ades, AE, Colbourn, Tim E., Bojke, L., Claxton, K., Philips, Z, Bojke, Laura   +23 more
core   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Comparative Efficacy of Parenteral and Mucosal Recombinant Probiotic Vaccines Against SARS-CoV-2 and S. pneumoniae Infections in Animal Models

Vaccines
Background: The accumulation of specific IgG antibodies in blood serum is considered a key criterion for the effectiveness of vaccination. For several vaccine-preventable infections, quantitative indicators of the humoral response have been established ...
Galina Leontieva, Tatiana Kramskaya, Tatiana Gupalova, Elena Bormotova, Yulia Desheva, Dmitry Korzhevsky, Olga Kirik, Irina Koroleva, Sergey Borisevitch, Alexander Suvorov   +9 more
doaj   +1 more source