Results 81 to 90 of about 1,747,691 (292)

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Physicians Infrequently Adhere to Hepatitis Vaccination Guidelines for Chronic Liver Disease [PDF]

, 2013
Background and Goals:Hepatitis A (HAV) and hepatitis B (HBV) vaccination in patients with chronic liver disease is an accepted standard of care. We determined HAV and HBV vaccination rates in a tertiary care referral hepatology clinic and the impact of ...
Dhiraj Yadav, Behari, J, Yadav, D, Sweeney Kaitlyn, Thudi Kavitha, Yadav Dhiraj, Kavitha Thudi, Jaideep Behari, Sweeney, Kaitlyn, Thudi, K, Behari, Jaideep, Thudi, Kavitha, Behari Jaideep, Yadav, Dhiraj, Kaitlyn Sweeney, Sweeney, K   +15 more
core   +2 more sources

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective. [PDF]

, 2011
Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of ...
Kerac, Marko, Zanuzdana, A, Augustine, G, Kim, Sophie, Mukaigawara, M, Denness, H, Harris, Rebecca C., Parish, V, Stevenson, Charlotte, Wigglesworth, N, Haroon, M, Paul Fisher, Javier Peñalver, Beck, Charles R., Gemma Morgan, Charlotte Stevenson, Butt, Mobasher, Puleston, Richard, Vivienne Parish, Haroon, S, Rebecca C Harris, Hiroshi Horiuchi, Ahyow, L, Bruce C McKenzie, Jose Figureroa, Joanne Enstone, Marko Kerac, Puleston, R, Dabke, G, Figureroa, Jose, Hashim, Ahmed B., Nguyen-Van-Tam, JS, Ishola, David A, Peñalver, Javier, Figureroa, J, Mobasher Butt, Mary O'Brien, Hird, C, Laura Béchard-Evans, Harris, Rebecca, Wigglesworth, Neil, Glenda Augustine, Richard Puleston, Ishola, DA, Isba, Rachel, Felix Greaves, Peñalver, J, Sophie Kim, McKenzie, Bruce C., Béchard-Evans, L, Agboado, Gabriel, Weston, Rachel, Orton, Elizabeth, Liz Lingard, Caroline Hird, Stevenson, C, Augustine, Glenda, O'Boyle, J, Hashim, Ahmed B, Dabke, Girija, Rachel Isba, Morgan, Gemma, Theaker, S, Ishola, David A., Kerac, M, O'Brien, Mary, Mitsuru Mukaigawara, Elizabeth Orton, Beck, Charles, Theaker, Sarah, Rosser, Julia, Vinogradova, Yana, Siobhan Farmer, Dean Wallace, Horiuchi, Hiroshi, Weston, R, Vinogradova, Y, Béchard-Evans, Laura, Sophie Haroon, Wallace, D, O'Boyle, Julie, Nguyen-Van-Tam, Jonathan S, Neil Wigglesworth, Haroon, Sophie, Hashim, Ahmed, Helene Denness, Wallace, Dean, Lingard, L, Zanuzdana, Arina, Munib Haroon, McKenzie, Bruce C, Nguyen-Van-Tam, Jonathan, Agboado, G, Horiuchi, H, David A Ishola, Harris, Rebecca C, Gabriel Agboado, Rachel Weston, Yana Vinogradova, Nguyen-Van-Tam, Jonathan S., Robert Howard, Beck, CR, Orton, E, Kim, S, Lauren Ahyow, Jonathan S Nguyen-Van-Tam, Roberts, Jonathan, Fisher, P, Farmer, S, Jonathan Roberts, Ishola, David, Lingard, Liz, Enstone, Joanne, Howard, Robert, Greaves, Felix, Howard, R, Denness, Helene, Isba, R, Fisher, Paul, Enstone, J, Hird, Caroline, Julie O'Boyle, Harris, RC, Haroon, Munib, Mukaigawara, Mitsuru, Rosser, J, Girija Dabke, Arina Zanuzdana, Sarah Theaker, Butt, M, Greaves, F, McKenzie, BC, Ahyow, Lauren, Hashim, AB, Morgan, G, Farmer, Siobhan, Ahmed B Hashim, Charles R Beck, Beck, Charles R, Parish, Vivienne, Julia Rosser, McKenzie, Bruce, O'Brien, M, Roberts, J   +143 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Awareness of oral and genital human papillomavirus (HPV) infection in young adolescents prior to gender-neutral vaccination [PDF]

, 2020
Introduction: Oral human papillomavirus (HPV) and oropharyngeal cancer prevalence are increasing, particularly in men. Raising greater awareness of male HPV disease is perceived as an important intervention strategy.
Roberts, Ben., Knight, Gillian, Roberts, Ben   +2 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source