Results 51 to 60 of about 69,723 (240)

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Analysis of available animal testing data to propose peer-derived quantitative thresholds for determining adequate surveillance capacity for rabies

Scientific Reports, 2023
Historical targets for country-level animal rabies testing volumes were abandoned due to ethical and welfare concerns, and interpretation challenges of testing healthy animals.
Faisal S. Minhaj, Sarah C. Bonaparte, Cassandra Boutelle, Ryan M. Wallace   +3 more
doaj   +1 more source

Serum Neutralisation profiles of Straw-Coloured Fruit Bats (Eidolon helvum) against four Lineages of Lagos Bat Lyssavirus

International Journal of Infectious Diseases, 2022
Purpose: Bats are the natural reservoir hosts for many viral zoonotic pathogens including lyssaviruses that can cause the fatal disease rabies. Lagos bat lyssavirus (LBV), a member of phylogroup II lyssaviruses, has been classified into four lineages (A,
V.O. Ameh, G. Wu, H. Goharriz, A. Fooks, C.T. Sabeta, L. Mcelhinney   +5 more
doaj   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

What is rural? Examining the relationship between human populations and their inter-connectedness in the context of communicable disease transmission

International Journal of Health Geographics
Background Rurality and urbanicity are recognized determinants of public health outcomes that influence policy and resource allocation. However, many commonly used methods to classify the rural-urban continuum, such as the Rural-Urban Commuting Area ...
Cassandra Boutelle, Patrick Corbett, Andrew Gibson, Frederic Lohr, Catherine Swedberg, Jesse Blanton, Ryan Wallace   +6 more
doaj   +1 more source

Molecular and serological survey of lyssaviruses in Croatian bat populations

BMC Veterinary Research, 2018
Background Rabies is the only known zoonotic disease of bat origin in Europe. The disease is caused by species belonging to the genus Lyssavirus. Five Lyssavirus species, i.e., European bat lyssavirus (EBLV)-1, EBLV-2, Bokeloh bat lyssavirus, Lleida bat ...
Ivana Šimić, Ivana Lojkić, Nina Krešić, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Anđela Ćukušić, Vida Zrnčić, Tomislav Bedeković   +8 more
doaj   +1 more source

Viral Metagenomic Profiling of Croatian Bat Population Reveals Sample and Habitat Dependent Diversity

Viruses, 2020
To date, the microbiome, as well as the virome of the Croatian populations of bats, was unknown. Here, we present the results of the first viral metagenomic analysis of guano, feces and saliva (oral swabs) of seven bat species (Myotis myotis, Miniopterus
Ivana Šimić, Tomaž Mark Zorec, Ivana Lojkić, Nina Krešić, Mario Poljak, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Vida Zrnčić, Anđela Ćukušić, Tomislav Bedeković   +10 more
doaj   +1 more source

Molecular Characterization of Lyssaviruses Originating from Domestic and Wild Cats Provides an Insight on the Diversity of Lyssaviruses and a Risk of Rabies Transmission to Other Susceptible Mammals and Humans in South Africa

Pathogens, 2023
Rabies is one of the most significant public and veterinary health problems, causing approximately 59,000 human deaths annually in the developing countries of Asia and Africa.
Kefentse Tsie, Ernest Ngoepe, Baby Phahladira, Nelisiwe Khumalo, Claude Sabeta   +4 more
doaj   +1 more source

Frequency analysis of cytolytic T lymphocyte precursors (CTL-P) generated in vivo during lethal rabies infection of mice. II. Rabies virus genus specificity of CTL-P [PDF]

, 1984
Cytolytic T lymphocyte precursors (CTL-P) were sensitized in vivo by intraplantar infection of C57BL/6 mice with a lethal dose of rabies virus, strain ERA (ERA).
Reddehase, M. J., Koszinowski, Ulrich H., James H. Cox, Cox, James H., Koszinowski, U. H., Matthias J. Reddehase, Ulrich H. Koszinowski   +6 more
core   +1 more source