Results 31 to 40 of about 43,348 (195)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Analysis of available animal testing data to propose peer-derived quantitative thresholds for determining adequate surveillance capacity for rabies

Scientific Reports, 2023
Historical targets for country-level animal rabies testing volumes were abandoned due to ethical and welfare concerns, and interpretation challenges of testing healthy animals.
Faisal S. Minhaj, Sarah C. Bonaparte, Cassandra Boutelle, Ryan M. Wallace   +3 more
doaj   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Serum Neutralisation profiles of Straw-Coloured Fruit Bats (Eidolon helvum) against four Lineages of Lagos Bat Lyssavirus

International Journal of Infectious Diseases, 2022
Purpose: Bats are the natural reservoir hosts for many viral zoonotic pathogens including lyssaviruses that can cause the fatal disease rabies. Lagos bat lyssavirus (LBV), a member of phylogroup II lyssaviruses, has been classified into four lineages (A,
V.O. Ameh, G. Wu, H. Goharriz, A. Fooks, C.T. Sabeta, L. Mcelhinney   +5 more
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

What is rural? Examining the relationship between human populations and their inter-connectedness in the context of communicable disease transmission

International Journal of Health Geographics
Background Rurality and urbanicity are recognized determinants of public health outcomes that influence policy and resource allocation. However, many commonly used methods to classify the rural-urban continuum, such as the Rural-Urban Commuting Area ...
Cassandra Boutelle, Patrick Corbett, Andrew Gibson, Frederic Lohr, Catherine Swedberg, Jesse Blanton, Ryan Wallace   +6 more
doaj   +1 more source

Molecular and serological survey of lyssaviruses in Croatian bat populations

BMC Veterinary Research, 2018
Background Rabies is the only known zoonotic disease of bat origin in Europe. The disease is caused by species belonging to the genus Lyssavirus. Five Lyssavirus species, i.e., European bat lyssavirus (EBLV)-1, EBLV-2, Bokeloh bat lyssavirus, Lleida bat ...
Ivana Šimić, Ivana Lojkić, Nina Krešić, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Anđela Ćukušić, Vida Zrnčić, Tomislav Bedeković   +8 more
doaj   +1 more source

Viral Metagenomic Profiling of Croatian Bat Population Reveals Sample and Habitat Dependent Diversity

Viruses, 2020
To date, the microbiome, as well as the virome of the Croatian populations of bats, was unknown. Here, we present the results of the first viral metagenomic analysis of guano, feces and saliva (oral swabs) of seven bat species (Myotis myotis, Miniopterus
Ivana Šimić, Tomaž Mark Zorec, Ivana Lojkić, Nina Krešić, Mario Poljak, Florence Cliquet, Evelyne Picard-Meyer, Marine Wasniewski, Vida Zrnčić, Anđela Ćukušić, Tomislav Bedeković   +10 more
doaj   +1 more source

Revealing the complexity of vampire bat rabies “spillover transmission”

Infectious Diseases of Poverty, 2023
Background The term virus ‘spillover’ embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new, naïve yet susceptible and permissive host species.
Luis E. Escobar, Andres Velasco-Villa, Panayampalli S. Satheshkumar, Yoshinori Nakazawa, Paige Van de Vuurst   +4 more
doaj   +1 more source