Results 51 to 60 of about 3,395,263 (313)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Examining ‘Race’ in Health Research: the case for ‘listening’ to language [PDF]
, 2006 Health researchers must be constantly conscious of the contribution that they may or may not make to the politics of race through language. In order to unpack concepts such as multiculturalism race relations ethnic minority citizenship and so forth at ...
Jones, Kip
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Social Inclusion, 2015 This essay pushes beyond the black-white binary in an effort to expand understandings into the relationship between sport, Latinidad, and global capitalism in the 21st century.
Jorge E. Moraga
doaj +1 more source
Why are the Children Dying?: Mixed-Race Children in Chang-rae Lee’s First Five Novels [PDF]
, 2017 The mixed-race children in each of Lee’s first five novels constitute an overarching set of symbols, reflecting, at first, society’s intolerance of miscegenation and its resulting mixed offspring, as demonstrated in the dysfunctional behaviors of the ...
Martin, Holly E
core +1 more source
The Law and Economics of Critical Race Theory [PDF]
, 2003 Legal academics often perceive law and economics (L&E) and critical race theory (CRT) as oppositional discourses. Using a recently published collection of essays on CRT as a starting point, we argue that the understanding of workplace discrimination ...
Carbado, Devon W., Gulati, Mitu
core +3 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Frontiers in Robotics and AIThis study presents an experience-based hierarchical-structure optimization algorithm to address the robotic system environment design problem, which combines motion planning and environment arrangement problems together.
Jiaxi Lu +3 more
doaj +1 more source