Results 61 to 70 of about 3,429,796 (315)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

How to arrange the robotic environment? Leveraging experience in both motion planning and environment optimization

Frontiers in Robotics and AI
This study presents an experience-based hierarchical-structure optimization algorithm to address the robotic system environment design problem, which combines motion planning and environment arrangement problems together.
Jiaxi Lu, Ryota Takamido, Yusheng Wang, Jun Ota   +3 more
doaj   +1 more source

Race Matters: What's Race Got to Do With It? [PDF]

, 2010
Outlines steps for determining whether a disparity is the result of unequal opportunities by race, including controlling for other variables, examining competing hypotheses, separating diversity and equity issues, and using the Race Matters Fact ...

core  

Pointer Race Freedom

, 2015
We propose a novel notion of pointer race for concurrent programs manipulating a shared heap. A pointer race is an access to a memory address which was freed, and it is out of the accessor's control whether or not the cell has been re-allocated.
Haziza, Frédéric, Holík, Lukáš, Meyer, Roland, Wolff, Sebastian   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Editorial

RACE: Revista de Administração, Contabilidade e Economia, 2017
Editorial
Lindomar da Silva, Sandro Bergue, Suylan Midlej   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Feedback within 24 hours [PDF]

It is widely accepted that feedback to students’ work works best when it is received quickly, while they still remember clearly what they were trying to do in their ...
Race, P
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source