Results 61 to 70 of about 822,094 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Environmental occurrence and fate of west nile virus RNA in wastewater systems

Frontiers in Environmental Science
West Nile virus (WNV) is a mosquito-borne flavivirus that has become a significant public health concern worldwide. The growing evidence suggests that WNV can also be released through urine, raising the possibility of shedding through environmental ...
Gennaro Trancone, Francesco Bianco, Francesco Bianco, Marco Race, Marco Race   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

O CARIBE NA VIRADA DO SÉCULO XX COMO LABORATÓRIO DA MODERNIDADE: sobre enclaves urbano-agrários e a hinterland (trans)nacional

Revista Brasileira do Caribe, 2014
No ano de 1998, finalizada a Guerra Hispano Americana, o Caribe ofereceu uma nova visibilidade. Um importante papel para a sua re emergência como significante região geo-polítca tive a estratégia de expansão das empresas multinacionais, tal como a United
Liliana Gómez
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Institutional Ethnography Research in Global South Settings

International Journal of Qualitative Methods, 2016
Within institutional ethnography (IE), texts—reproducible written and graphic materials—are understood to play a central role in coordinating social relationships.
Sarah Rudrum
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

'Jami Chadiba Nahin' (We Will Not Leave this Land): Materiality and Imagination in Indigenous Land Ethics

New Area Studies
This is a reflective essay on materiality and imagination of Indigenous land ethics as expressed in global Indigenous writing.  I explore Adivasi land ethics, particularly from the contexts of Odisha and Jharkhand, placing them alongside North American ...
Ananya Mishra
doaj   +1 more source

Race [PDF]

Journal of Thrombosis and Haemostasis, 2017
F R, Rosendaal, P H, Reitsma
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source