Results 81 to 90 of about 659,412 (245)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Influence of Participatory Decision-Making on Performance of HIV/AIDS Community Health Projects in Kisumu County, Kenya

European Journal of Management Issues
Purpose. There are efforts to combat HIV/AIDS through Sustainable Development Goals and so, HIV/AIDS community health projects have been implemented to shape HIV/AIDS management and care.
Grace Ojall Odawa, Charles Mallans Rambo, Lillian Otieno-Omutoko, Salome Wambui Richu   +3 more
doaj  

From raw data to actionable insights: preprocessing real-world data for machine learning in diabetes care

Frontiers in Digital Health
BackgroundMachine Learning (ML) applied to healthcare Real World Data (RWD) may improve patient management. RWD, however, requires extensive preprocessing to make it ML-ready. Our aim was to explore the impact of preprocessing on ML models applied to RWD
Marco Montagna, Marco Montagna, Aleksandar Svilenov Rabadzhiev, Alberto Traverso, Emanuela Setola, Edoardo Draetta, Alessio Dimonte, Simone Barbieri, Bruno Fabiani, Lorenzo Piemonti, Lorenzo Piemonti, Antonio Esposito, Antonio Esposito, Carlo Tacchetti, Carlo Tacchetti, Patrizia Rovere Querini, Patrizia Rovere Querini   +16 more
doaj   +1 more source

“I Thought We Had No Rights” – Challenges in Listening, Storytelling, and Representation of LGBT Refugees

Studies in Social Justice, 2015
Storytelling serves as a vital resource for Lesbian, Gay, Bisexual and Trans* (LGBT) refugees’ access to asylum. It is through telling their personal stories to the Canadian Immigration and Refugee Board that LGBT refugees’ claims for asylum are accessed
Katherine Fobear
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Race [PDF]

Journal of Thrombosis and Haemostasis, 2017
F R, Rosendaal, P H, Reitsma
openaire   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

O CARIBE NA VIRADA DO SÉCULO XX COMO LABORATÓRIO DA MODERNIDADE: sobre enclaves urbano-agrários e a hinterland (trans)nacional

Revista Brasileira do Caribe, 2014
No ano de 1998, finalizada a Guerra Hispano Americana, o Caribe ofereceu uma nova visibilidade. Um importante papel para a sua re emergência como significante região geo-polítca tive a estratégia de expansão das empresas multinacionais, tal como a United
Liliana Gómez
doaj