Results 51 to 60 of about 504,265 (307)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Longitudinal NMR-based Metabolomics Analysis of Male Mountain Ultramarathon Runners: New Perspectives for Athletes Monitoring and Injury Prevention

Sports Medicine - Open
Background The aim of this study was to explore how a metabolomic approach could provide valuable information on changes in the athletes' metabolome during a mountain ultramarathon race.
Matthieu Schoumacher, Julie Nguyen, Eric Brevers, Arianna Cirillo, Manon Campas, Elodie Grifnée, Justine Demeuse, Loreen Huyghebaert, Philippe Massonnet, Thomas Dubrowski, Joy Ledeck, Stéphanie Peeters, Grégoire P. Millet, Pierre Croisille, Jean-François Kaux, Pascal de Tullio, Etienne Cavalier, Caroline Le Goff   +17 more
doaj   +1 more source

In its focus on genetics and race, global newspaper coverage of athletics is far from “post-racial” [PDF]

, 2015
With the years of racially segregated sports now long behind us, many would consider that sports coverage is color-blind and post-racial. In new research which examines newspaper coverage of race, sport and genetics from 2003 to 2014, Matthew W.
Goss, Devon R., Hughley, Matthew W.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Learning From Early Attempts to Generalize Darwinian Principles to Social Evolution [PDF]

, 2009
Copyright University of Hertfordshire & author.Evolutionary psychology places the human psyche in the context of evolution, and addresses the Darwinian processes involved, particularly at the level of genetic evolution.
Aldrich H. E., Aldrich H. E., Alexander S., Archer M. S., Aunger R., Bagehot W., Baldwin J. M., Bannister R. C., Bergstrom T. C., Berle A. A., Blackmore S., Bogdan R., Boyd R., Campbell D. T., Campbell D. T., Childe V. G., Commons J. R., Cziko G., Darwin C. R., Darwin C. R., Dawkins R., Dawkins R., Degler C. N., Dennett D. C., Dorfman J., Drummond H., Durham W. H., Edelman G. M., Geoffrey M. Hodgson, Godfrey-smith P., Hayek F. A., Henrich J., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hodgson G. M., Hull D. L., Hull D. L., James W., Keller A. G., Keller A. G., Kidd B., Knudsen T., Kontopoulos K. M., Lewes G. H., Lewontin R. C., Morgan C. L., Nelson R. R., Penrose E. T., Plotkin H. C., Popper K. R., Price G. R., Richards R. J., Sanderson S. K., Sober E., Sober E., Sober E., Sperber D., Sterelny K., Veblen T. B., Veblen T. B., Veblen T. B., Veblen T. B., Webb S. J., Weismann A., Weissman D.   +70 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

What are the principles that govern life?

Communicative & Integrative Biology, 2020
We know that living matter must behave in accordance with the universal laws of physics and chemistry. However, these laws are insufficient to explain the specific characteristics of the vital phenomenon and, therefore, we need new principles, intrinsic ...
Jaime Gómez-Márquez
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Nineteenth century US BMIs by race: Socioeconomics and biology [PDF]

, 2012
Little research exists on late 19th and early 20th century US body mass index value differences by race, and darker complexions were associated with greater BMI values.
Carson, Scott A.
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source