Results 71 to 80 of about 504,265 (307)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Environmental education in teacher training level through the race Biology-Geography
Maestro y Sociedad, 2017 This works directed to the teaching learning process perfection at the Santiago pedagogical Branch at media level course in Biology-Geography can seer from many insufficiencies that face the students in formation, taking into account that after two years
Lidia Quesada-Martínez +2 more
doaj
Race and ethnicity in biology research mentoring relationships.
Journal of Diversity in Higher Education, 2020 This case study investigated how mentors and mentees in biology experience and understand race and ethnicity in their research mentoring relationships. Semi-structured interviews were conducted with mentors (n = 23) and mentees (n = 15) who had participated in an undergraduate biology summer research opportunity program at a large Midwestern research ...
Angela, Byars-Winston +5 more
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Summary and reflections on the ”Linnaeus debate” in Sweden 2020/2021
Sjuttonhundratal, 2021 Annika Windahl Pontén
doaj +1 more source
, 2018 A basic challenge to naturalistic moral realism is that, even if moral properties existed, there would be no way to naturalistically represent or track them.
Bloomfield, Paul
core +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Synthetic Biology: A Novel Approach for the Construction of Industrial Microorganisms
Food Technology and Biotechnology, 2013 The recent achievement of synthesising a functioning bacterial chromosome marks a coming of age for engineering living organisms. In the future this should allow the construction of novel organisms to help solve the problems facing the human race ...
Antonio Starcevic +9 more
doaj
Students’ perceptions of social issues in biology courses
Journal of Microbiology & Biology EducationStudents’ scientific literacy may be improved by the integration of social issues into biology courses, enabling them to make informed decisions on social issues in the context of their scientific knowledge.
Stacy Tran +3 more
doaj +1 more source