Results 61 to 70 of about 514,952 (262)

Discrete Model of Paired Relay-Race

Bulletin of the South Ural State University. Series "Mathematical Modelling, Programming and Computer Software", 2018
Summary: The case of the active and passive team relay-race, in which an active team operates in accordance with rigid schedule and a passive team overcome the stage of its distance at randomly selected alternative routs during occasional time intervals is considered.
Larkin, E. V., Bogomolov, A. V., Privalov, A. N., Dobrovolsky, N. N.   +3 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Model-Based Optimization of Velocity Strategy for Lightweight Electric Racing Cars

Journal of Advanced Transportation, 2018
The article presents a method for optimizing driving strategies aimed at minimizing energy consumption while driving. The method was developed for the needs of an electric powered racing vehicle built for the purposes of the Shell Eco-marathon (SEM), the
Mirosław Targosz, Wojciech Skarka, Piotr Przystałka   +2 more
doaj   +1 more source

Modeling Infant i's Look on Trial t: Race-Face Preference Depends on i's Looking Style

Frontiers in Psychology, 2017
When employing between-infant designs young infants' looking style is related to their development: Short looking (SL) infants are cognitively accelerated over their long looking (LL) peers. In fact, looking style is a within-infant variable, and depends
Hoben Thomas, Ina Fassbender
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Understanding and mitigating the impact of race with adversarial autoencoders

Communications Medicine
Background Artificial intelligence carries the risk of exacerbating some of our most challenging societal problems, but it also has the potential of mitigating and addressing these problems.
Kathryn Sarullo, S. Joshua Swamidass
doaj   +1 more source

Real-Time Performance Prediction in Long-Distance Trail Running: A Practical Model Based on Terrain Difficulty and Pacing Variability

Sports
Trail running is a demanding endurance sport where performance prediction models often rely on laboratory testing or pre-race data, limiting their practical application. This study presents a real-time predictive model for marathon and ultra-trail races,
Héctor Gutiérrez, Eduardo Piedrafita, Pablo Jesús Bascuas, Irela Arbonés, César Berzosa, Ana Vanessa Bataller-Cervero   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source