Results 271 to 280 of about 215,101 (350)

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Intersectionality, equity-mindedness, and access to care. [PDF]

Front Vet Sci
Nishi NW, Watley E, Collier MJ, Morales GI.   +3 more
europepmc   +1 more source

Few Steps, Big Impact: Recent Advances in the Streamlined Synthesis of Multiply Chiral Heterohelicenes with Tunable Optoelectronic Properties

Chemistry–Methods, EarlyView.
Heterohelicenes with multiple chiral axes have the potential to drive next‐generation technologies due to their unique structural and optoelectronic features. This review highlights innovative short‐step synthetic strategies for double and triple heterohelicenes, emphasizing their ease of preparation and valuable (chir)optical features, along with high
Mohamed S. H. Salem, Shinobu Takizawa
wiley   +1 more source

Associations Between Experiences of Racial Discrimination Across the Life Course and Mental Health: Exploring Direct and Indirect Pathways. [PDF]

Sociol Health Illn
Irizar P, Kapadia D, Taylor H, Wafula G, Kwaku-Odoi C, Bécares L, Katikireddi SV.   +6 more
europepmc   +1 more source

A Base‐Mediated Rearrangement of the Benzylic 1,5‐Hexadipyridynyl Moiety

ChemPlusChem, EarlyView.
A rearrangement unheard of! When exposed to base, benzylic 1,5‐hexadipyridynyl moieties skip a beat—disregarding Cope‐like rearrangement and instead readily rearrange through a deprotonation–reprotonation–electrocyclization cascade. The result is a highly rigid vinyl‐pyridine cyclobutene, fashioned via a novel pathway.A previously unrecognized base ...
Wouter A. Remmerswaal, Thai‐Tony Nguyen, Zijian Han, Fedor Krasovski Slobodian, Ruisheng Xiong, Vadim Kessler, Zhijian Xu, Weiliang Zhu, Mate Erdelyi   +8 more
wiley   +1 more source

Cytochrome P450 2D6 *17 and *29 Allele Activity for Risperidone Metabolism: Advancing Precision Medicine Health Equity

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde, Samuel E. Vaughn, Ogochukwu Amaeze, Paul Toren, Brandon Retke, Akinyemi Oni‐Orisan, Laura B. Ramsey   +6 more
wiley   +1 more source

Health Disparities at the Intersection of Racism, Social Determinants of Health, and Downstream Biological Pathways. [PDF]

Int J Environ Res Public Health
Thorpe RJ, Bruce MA, Wilder T, Jones HP, Thomas Tobin C, Norris KC.   +5 more
europepmc   +1 more source

Curriculum guidelines for the development of student agency in secondary education: A systematic review

The Curriculum Journal, EarlyView.
Abstract To prepare students for lifelong learning, and their role in society, student agency has been foregrounded as an important aim of secondary education. In general, student agency is seen as the will and skill to intentionally transform one's functioning or circumstances.
A. J. M. Schoots‐Snijder, E. H. Tigelaar, W. F. Admiraal   +2 more
wiley   +1 more source

Racial issues in psychiatry: a thematic analysis of an initial health equity educational activity for medical students. [PDF]

BMC Med Ethics
Pickerl P, Sorrell T, Blue M, Patterson K, Sheth N, Givens S.   +5 more
europepmc   +1 more source

School spaces of dissensus: Protecting sexualities education in anti‐gender, anti‐Muslim and de‐democratising times

The Curriculum Journal, EarlyView.
Abstract This paper examines the intensified conflict over sexualities education curricula brought about by anti‐(trans)gender and anti‐Muslim policy and political discourse transnationally. Backlash against inclusive sexualities education has taken shape across several policy territories, driven in part by de‐democratising right‐wing populist ...
James Sutton, Deborah Youdell, Karl Kitching   +2 more
wiley   +1 more source