Results 51 to 60 of about 343,927 (326)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang   +13 more
wiley   +1 more source

Seismic Analysis of HFETR Spent Fuel Storage Rack Based on Parameterization-superelement Method

open access: yesYuanzineng kexue jishu, 2022
In order to solve the problems in the design of HFETR spent fuel storage rack, such as slow iterative design speed, long seismic analysis time and difficult multirack analysis, a combination of parameterization method and superelement method was ...
LIU Jinlong;ZHANG Hangzhou;WANG Shuai;SUN Zhijun;LONG Tao
doaj  

Automated Benchmarking of Variable‐Property Soft Robotic Fingertips to Enable Task‐Optimized Sensor Selection

open access: yesAdvanced Science, EarlyView.
Sensorized fingertips are needed to unlock robotic dexterity, versatility, and diverse interactions. Here, 15 identically‐shaped robotic fingertips are benchmarked by a fully automated toolchange system, covering eight different materials and six broadly‐ranging sensing mechanisms.
David Hardman   +5 more
wiley   +1 more source

Laboratory glassware rack for seismic safety [PDF]

open access: yes, 1985
A rack for laboratory bottles and jars for chemicals and medicines has been designed to provide the maximum strength and security to the glassware in the event of a significant earthquake.
Cohen, M. M.
core   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

open access: yesAdvanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang   +13 more
wiley   +1 more source

Research on Meshing Characteristics of Trochoidal Roller Pinion Rack Transmission

open access: yesApplied Sciences, 2022
As a precision transmission mechanism, the trochoidal roller pinion rack has been paid more and more attention in recent years, but its meshing characteristics have not been deeply explored.
Haiwei Wang, Lulu Li, Geng Liu
doaj   +1 more source

Self-locking telescoping manipulator arm [PDF]

open access: yes, 1985
A telescoping manipulator arm and pivotable finger assembly are disclosed. The telescoping arm assembly includes a generally T-shaped arm having three outwardly extending fingers guided on grooved roller guides to compensate for environmental variations.
Nesmith, M. F.
core   +1 more source

An enumeration process for racks

open access: yes, 2018
Given a presentation for a rack $\mathcal R$, we define a process which systematically enumerates the elements of $\mathcal R$. The process is modeled on the systematic enumeration of cosets first given by Todd and Coxeter.
Hoste, Jim, Shanahan, Patrick D.
core   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

open access: yesAdvanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang   +18 more
wiley   +1 more source

Plant Robotics for Sustainable and Environmentally Friendly Robots: Insights from Actuation Characteristics

open access: yesAdvanced Science, EarlyView.
Plants are promising materials for building sustainable and eco‐friendly robots due to their inherent multifunctionality, with actuation playing a crucial role. This article focuses on the physical movements of plants and, from the perspective of actuation characteristics, explores representative plant species and their behaviors, the current state of ...
Kazuya Murakami   +8 more
wiley   +1 more source

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