Results 31 to 40 of about 99,944 (264)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Radial basis function neural networks: a topical state-of-the-art survey
Open Computer Science, 2016 Radial basis function networks (RBFNs) have gained widespread appeal amongst researchers and have shown good performance in a variety of application domains. They have potential for hybridization and demonstrate some interesting emergent behaviors.
Dash Ch. Sanjeev Kumar +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
An Embedded Neural Network Approach for Reinforcing Deep Learning: Advancing Hand Gesture Recognition [PDF]
Journal of Universal Computer ScienceDeep neural networks (DNNs) can face limitations during training for recognition, motivating this study to improve recognition capabilities by optimizing deep learning features for hand gesture image recognition. We propose a novel approach that enhances
Anwar Mira, Olaf Hellwich
doaj +3 more sources
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Application of Radial Basis Function Network for the Modeling and Simulation of Turbogenerator
Journal of Advances in Information Technology, 2013 In this paper, the applicability of Radial Basis Function (RBF) network for the modeling and simulation of turbogenerators is presented. It is expensive and time- consuming to do experimental work to predict the behaviour of Turbogenerators with changing
Mohsen Hayati, Abbas Rezaei, Leila Noori
doaj +1 more source
Mean Dimension of Radial Basis Functions
SIAM Journal on Numerical AnalysisWe show that generalized multiquadric radial basis functions (RBFs) on $\mathbb{R}^d$ have a mean dimension that is $1+O(1/d)$ as $d\to\infty$ with an explicit bound for the implied constant, under moment conditions on their inputs. Under weaker moment conditions the mean dimension still approaches $1$.
Christopher R. Hoyt, Art B. Owen
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown +6 more
wiley +1 more source