Results 51 to 60 of about 205,887 (267)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Capacitor Allocation Using Multiobjective Water Cycle Algorithm and Fuzzy Logic

Elektronika ir Elektrotechnika, 2022
Radial distribution systems are susceptible to a lack of voltage profile and increase system losses, particularly at the distant ends of the distribution feeder.
Menna Allah E. Mohamed El-Saeed, Amal F. Abdel-Gwaad, Mohamed A. Farahat   +2 more
doaj   +1 more source

Piped water cooling of concrete dams [PDF]

, 2004
Piped water is used to remove hydration heat from concrete dams during construction. By examining simple models we obtain an estimate for the temperature rise along the pipe network and within the concrete.
Ballim, Y., Charpin, J., Fitt, A.D., Fowkes, N., Myers, T., Patini, A.P.   +5 more
core  

Popularity versus Similarity in Growing Networks

, 2013
Popularity is attractive -- this is the formula underlying preferential attachment, a popular explanation for the emergence of scaling in growing networks.
A Clauset, A Vázquez, A-L Barabási, AE Motter, AFJ van Raan, AK Menon, B Bollobás, D Crandall, DJ Watts, Dmitri Krioukov, F Bonahon, F Menczer, F Menczer, Fragkiskos Papadopoulos, G Bianconi, G Caldarelli, H Jeong, K Börner, LA Adamic, M McPherson, M. Ángeles Serrano, Maksim Kitsak, Marián Boguñá, MEJ Newman, O Simşek, PL Krapivsky, R Pastor-Satorras, R Pastor-Satorras, RM D'Souza, S Fortunato, S Redner, SN Dorogovtsev, SN Dorogovtsev, SN Dorogovtsev   +33 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A Swarm Approach for Improving Voltage Profiles and Reduce Power Loss on Electrical Distribution Networks

IEEE Access, 2018
As a mean to provide reactive power compensation to radial distribution networks, capacitor banks are commonly installed within these electrical distribution systems.
Primitivo Diaz, Marco Perez-Cisneros, Erik Cuevas, Octavio Camarena, Fernando Abraham Fausto Martinez, Adrian Gonzalez   +5 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Branching principles of animal and plant networks identified by combining extensive data, machine learning, and modeling

, 2020
Branching in vascular networks and in overall organismic form is one of the most common and ancient features of multicellular plants, fungi, and animals.
Bentley, Lisa P., Brummer, Alexander B, Buzzard, Vanessa, Enquist, Brian J., Gray, Andrew, Lymperopoulos, Panagiotis, Oliveras, Imma, Savage, Van M., Shen, Jocelyn, Tekin, Elif   +9 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source