Results 51 to 60 of about 5,695,707 (294)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

From treeline to species line: Thermal patterns and growth relationships across the krummholz zone of whitebark pine, Sierra Nevada, California, USA

Arctic, Antarctic, and Alpine Research, 2020
A multiyear study of forest-to-alpine ecotones across extensive krummholz zones in whitebark pine (WBP; Pinus albicaulis), Sierra Nevada, California, resolved mean treeline growing season temperature (GST) of 9.3°C, 2.6°C warmer than global thresholds ...
Constance I. Millar, Diane L. Delany, Robert D. Westfall   +2 more
doaj   +1 more source

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma [PDF]

Journal of Clinical Investigation, 2007
Melanoma is the cancer with the highest increase in incidence, and transformation of radial growth to vertical growth (i.e., noninvasive to invasive) melanoma is required for invasive disease and metastasis. We have previously shown that p42/p44 MAP kinase is activated in radial growth melanoma, suggesting that further signaling events are required for
Govindarajan, B., Sligh, J.E., Vincent, B.J., Li, M., Canter, J.A., Nickoloff, B.J., Rodenburg, R.J.T., Smeitink, J.A.M., Oberley, L., Zhang, Y., Slingerland, J., Arnold, R.S., Lambeth, J.D., Cohen-Bendahan, C.C.C., Hilenski, L., Griendling, K., Martinez-Diez, M., Cuezva, J.M., Arbiser, J.L.   +18 more
openaire   +4 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Radial growth of subarctic tree and shrub species: relationships with climate and association with the greening of the forest–tundra ecotone of subarctic Québec, Canada

Arctic Science
Climate change has resulted in a widespread increase in primary productivity in northern regions. This “greening” can alter terrestrial ecosystems dynamics and trigger positive climate feedbacks but often exhibits spatial heterogeneity.
Julie-Pascale Labrecque-Foy, Anna Gaspard, Martin Simard, Stéphane Boudreau   +3 more
doaj   +1 more source

On radial stationary solutions to a model of non-equilibrium growth [PDF]

European Journal of Applied Mathematics, 2013
We present the formal geometric derivation of a non-equilibrium growth model that takes the form of a parabolic partial differential equation. Subsequently, we study its stationary radial solutions by means of variational techniques. Our results depend on the size of a parameter that plays the role of the strength of forcing. For small forcing we prove
Escudero, C., Hakl, R. (Robert), Peral, I., Torres, P.J.   +3 more
openaire   +4 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

PRECISION MEASUREMENT OF RADIAL GROWTH AND DAILY RADIAL FLUCTUATIONS IN DOUGLAS FIR [PDF]

The Forestry Chronicle, 1950
The dial indicator, one of industry's precision tools, has been tested over a period of two and a half years to ascertain its suitability as a dendrometer. This study cannot claim to be the first of its kind, nor to yield exhaustive information, and on this basis the instrument should therefore neither be condemned nor accepted in full. The experience
G. Warrack, Chr. Joergensen
openaire   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Impact of mistletoe attack (Viscum album ssp. abietis) on the radial growth of silver fir. A case study in the North of Eastern Carpathians [PDF]

Annals of Forest Research, 2009
Viscum album ssp. abietis (Wiesb.) Abrom L. is one of the three subspecies of Viscum album L that is frequently encountered in Romanian forests. The mistletoe has notoriously negative effects on trees and forests health. The mistletoe infections not only
Catalina Barbu
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