Results 51 to 60 of about 317,601 (325)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Radial solutions and a local bifurcation result for a singular elliptic problem with Neumann condition

Electronic Journal of Qualitative Theory of Differential Equations
We study the problem $-\Delta u=\lambda u-u^{-1}$ with a Neumann boundary condition; the peculiarity being the presence of the singular term $-u^{-1}$.
Claudio Saccon
doaj   +1 more source

Structure of positive radial solutions including singular solutions to Matukuma's equation

Communications on Pure & Applied Analysis, 2005
We consider positive solutions of Matukuma's equation, which is described by a nonlinear elliptic equation with a weight. Any radially symmetric solution of this equation is said to be regular or singular according to its behavior near the origin and infinity. We investigate the structure of positive radial regular and singular solutions.
Hiroshi Morishita, Eiji Yanagida, Shoji Yotsutani   +2 more
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Positive radial solutions for Dirichlet problems via a Harnack‐type inequality

Mathematical Methods in the Applied Sciences, 2022
We deal with the existence and localization of positive radial solutions for Dirichlet problems involving ‐Laplacian operators in a ball. In particular, ‐Laplacian and Minkowski‐curvature equations are considered. Our approach relies on fixed point index techniques, which work thanks to a Harnack‐type inequality in terms of a seminorm.
Radu Precup, Jorge Rodríguez‐López
openaire   +3 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Bounded and large radially symmetric solutions for some (p,q)-Laplacian stationary systems

Electronic Journal of Differential Equations, 2012
This article concerns radially symmetric positive solutions of second-order quasilinear elliptic systems. In terms of the growth of the variable potential functions, we establish conditions such that the solutions are either bounded or blow up at ...
Adel Ben Dkhil, Noureddine Zeddini
doaj  

Positive radial solutions to a ‘semilinear’ equation involving the Pucci's operator

Journal of Differential Equations, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Felmer Aichele, Patricio, Quaas, Alexander   +1 more
openaire   +3 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source