Results 51 to 60 of about 3,838,081 (296)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Existence of infinitely many radial and non-radial solutions for quasilinear Schrödinger equations with general nonlinearity

Electronic Journal of Qualitative Theory of Differential Equations, 2017
In this paper, we prove the existence of many solutions for the following quasilinear Schrödinger equation \begin{equation*} -\Delta u - u\Delta(|u|^2) + V(|x|)u = f(|x|,u),\qquad x \in \mathbb{R}^N. \end{equation*} Under some generalized assumptions on $
Jianhua Chen, Xianhua Tang, Jian Zhang, Huxiao Luo   +3 more
doaj   +1 more source

On Positive Radial Solutions for a Class of Elliptic Equations [PDF]

The Scientific World Journal, 2014
A class of elliptic boundary value problem in an exterior domain is considered under some conditions concerning the first eigenvalue of the relevant linear operator, where the variables of nonlinear termfs,uneed not to be separated. Several new theorems on the existence and multiplicity of positive radial solutions are obtained by means of fixed point ...
Ying Wu, Guodong Han
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Proposed Method For Selecting The Clustering Algorithm In Radial Basis Function [QA223. A581 2008 f rb]. [PDF]

, 2008
Rangkaian Fungsi Asas Radial telah digunakan dengan meluas untuk menganggarkan dan mengelaskan data. Model biasa bagi Fungsi Asas Radial menentukan pusat, Radial Basis Function Networks have been widely used to approximate data and classify data.
Ang, Sau Loong
core   +1 more source

Existence and nonexistence of solutions for sublinear problems with prescribed number of zeros on exterior domains

Electronic Journal of Differential Equations, 2017
We prove existence of radial solutions of $\Delta u+K(r)f(u)=0$ on the exterior of the ball, of radius R, centered at the origin in $\mathbb{R}^{N}$ such that $\lim_{r \to \infty} u(r)=0$ if R>0 is sufficiently small.
Janak Joshi
doaj  

Computer Simulation System of Nonlinear Thermal Conductivity

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Математичне моделювання, інформаційні технології, автоматизовані системи управління, 2021
The article discusses the computer simulation system of nonlinear processes that described by the one-dimensional nonstationary heat equation with power-law nonlinearity.
Ірина Гарячевська, Денис Протектор, Емілія Усатенко   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Novel Numerical Method Based on the Analog Equation Method for a Class of Anisotropic Convection-Diffusion Problems

Frontiers in Physics, 2022
In this work, a CMFS method based on the analogy equation method, the radial basis function and the method of fundamental solutions for linear and nonlinear convection-diffusion equations in anisotropic materials is presented.
L Zhang, L Zhang, FZ Wang, FZ Wang, J Zhang, J Zhang, YY Wang, S Nadeem, TA Nofal   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source