Results 101 to 110 of about 3,123,602 (300)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Radial solutions for a nonlocal boundary value problem

Boundary Value Problems, 2006
We consider the boundary value problem for the nonlinear Poisson equation with a nonlocal term −Δu=f(u,∫Ug(u)), u|∂U=0. We prove the existence of a positive radial solution when f grows linearly in u, using Krasnoselskiiés fixed ...
Luís Sanchez, Ricardo Enguiça   +1 more
doaj   +2 more sources

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Existence of infinitely many radial solutions for quasilinear Schrodinger equations

Electronic Journal of Differential Equations, 2014
In this article we prove the existence of radial solutions with arbitrarily many sign changes for quasilinear Schrodinger equation $$ -\sum_{i,j=1}^{N}\partial_j(a_{ij}(u)\partial_iu) +\frac{1}{2}\sum_{i,j=1}^{N}a'_{ij}(u)\partial_iu\partial_ju+V(x ...
Gui Bao, Zhiqing Han
doaj  

Real-world evidence of SAINT® effectiveness in a heterogenous clinical population with psychiatric and medical comorbidities: A multicenter, open-label, community-based study

Journal of Mood and Anxiety Disorders
Objective: SAINT®, a functional connectivity-guided, accelerated form of intermittent theta-burst stimulation, has shown high efficacy in depression in open-label and randomized controlled trials.
Michael T. Feyder, Katy H. Stimpson, Andrew D. Geoly, T.J. Ford, Adi Maron-Katz, Evan Lutkenhoff, Robert G. Bota, David M. Carreon, Owen S. Muir, Carlene MacMillan, Ian A. Cook, Hugh B. Solvason, Rebecca M. Allen, Roger Pottanat, Tracy Barbour, Nolan R. Williams, Brandon S. Bentzley   +16 more
doaj   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Infinitely many radial solutions for a sub-super critical Dirichlet boundary value problem in a ball

Electronic Journal of Differential Equations, 2007
We prove the existence of infinitely many solutions to a semilinear Dirichlet boundary value problem in a ball for a nonlinearity $g(u)$ that grows subcritically for $u$ positive and supercritically for $u$ negative.
Chee Meng Tan, John Kwon, Alfonso Castro
doaj  

Triangular Index Ratio as an Alternative Method to the Alpha Angle for Defining the Presence of Cam Morphology: A Prospective Cohort Study

Arthritis Care &Research, EarlyView.
Objective Cam morphology, which is a significant risk factor for hip osteoarthritis, is commonly quantified by the alpha angle (AA). This study aims to explore the potential of the triangular index ratio (TIR) to quantify cam morphology on anteroposterior radiographs by assessing the association between TIR‐defined cam morphology and the development of
Jinchi Tang, Fleur Boel, Michiel M. A. van Buuren, Noortje S. Riedstra, Myrthe A. van den Berg, Jos Runhaar, Sita Bierma‐Zeinstra, Rintje Agricola   +7 more
wiley   +1 more source

Gradient radial basis function networks for nonlinear and nonstationary time series prediction

, 1995
We present a method of modifying the structure of radial basis function (RBF) network to work with non-stationary series that exhibit homogeneous non-stationary behaviour.
Chng, E. S., Mulgrew, B., S. Chen, E.S. Chng, B. Mulgrew, Chen, S.   +5 more
core  

Local solutions of the optimal power flow problem [PDF]

, 2013
The existence of locally optimal solutions to the AC optimal power flow problem (OPF) has been a question of interest for decades. This paper presents examples of local optima on a variety of test networks including modified versions of common networks ...
Waqquas A. Bukhsh, Grothey, Andreas, Paul A. Trodden, Bukhsh, Waqquas A., Trodden, Paul, Trodden, P., McKinnon, Kenneth, Trodden, Paul A., Bukhsh, Waqquas, Bukhsh, W., Grothey, A., McKinnon, K., Andreas Grothey, Ken I. M. McKinnon, McKinnon, Ken I.M.   +14 more
core   +1 more source