Results 31 to 40 of about 96,336 (267)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Elastic stress concentration at radial crossholes in pressurized thick cylinders [PDF]

The Journal of Strain Analysis for Engineering Design, 2007
Results of a parametric finite element analysis investigation of stress concentration at radial crossholes in pressurized cylinders are presented in numerical and graphical form. The analysis shows that the location of maximum stress does not generally occur at the junction between the bores, as is commonly supposed, but at some small distance up the ...
Comlekci, T., Mackenzie, D., Hamilton, R., Wood, J.   +3 more
openaire   +3 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Thermo-Mechanical Analysis for an Axisymmetric Functionally Graded Rotating Disc under Linear and Quadratic Thermal Loading [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2020
The study presents thermo-mechanical analysis of functionally graded (FG) rotating disc whose material properties, namely, Young’s modulus, density and coefficient of thermal expansion in radial direction are tailored from inner to outer radius using ...
Parth Dinesh Mehta, Manoj Sahni
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Mechanism of Interface Dilatancy of Cement Mortar Rockbolts

Advances in Civil Engineering, 2020
In this paper, the mechanism of the interface dilatancy of cement mortar rockbolts is studied based on the phenomenon of splitting failure of samples with a high sand content in the grouting material in laboratory tests.
Yubao Zhan, Nan Li, Hui Wang, Pengqiang Zheng, Jun Zhang, Qihua Liu   +5 more
doaj   +1 more source

All-fiber controller of radial polarization using a periodic stress [PDF]

Optics Letters, 2011
Our aim is to transpose the polarization control by mechanical stress usually applied to single mode fibers, to the (TM01, TE01,HEev21,HEod21) annular mode family. Nevertheless, the quasi degeneracy of these four modes makes the situation more complex than with the fundamental mode HE11.
Kalaidji, D., Spajer, M., Grosjean, T.
openaire   +5 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Numerical simulation study on liquid CO2 phase transition blasting under the action of in-situ stress

Meikuang Anquan
In order to clarify the mechanical properties and failure mechanism of coal (rock) under high ground stress conditions, a theoretical model was used to analyze the stress field distribution under the coupling effect of ground stress and CO2 phase change ...
Yan WANG
doaj   +1 more source

Exact and Numerical Elastic Analysis for the FGM Thick-Walled Cylindrical Pressure Vessels with Exponentially-Varying Properties

Archives of Metallurgy and Materials, 2016
Assuming exponential-varying properties in the radial direction and based on the elasticity theory, an exact closed-form analytical solution is obtained to elastic analysis of FGM thick-walled cylindrical pressure vessels in the plane strain condition ...
Nejad M. Zamani, Abedi M., Lotfian M.H., Ghannad M.   +3 more
doaj   +1 more source