Results 51 to 60 of about 96,336 (267)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Individuals with Multi‐Joint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data from the Canadian Longitudinal Study on Aging

Arthritis Care &Research, Accepted Article.
Objective Test the hypothesis that multi‐joint osteoarthritis would modify the relation between time and frailty progression, where more affected joints would lead to larger declines over 6‐years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Rules of fracture propagation of hydraulic fracturing in radial well based on XFEM

Journal of Petroleum Exploration and Production Technology, 2018
The radial well fracturing has been applied and achieved effective output. However, the fracture morphology and propagation law of it are still remain unclear, which limits the development and application of it.
Xiaolong Li, Wen Xiao, Zhanqing Qu, Tiankui Guo, Jianxiong Li, Wei Zhang, Yu Tian   +6 more
doaj   +1 more source

Pyramidal Structures on Yttria‐Stabilized Zirconia after High Temperature Exposure at 1500°C: New Features on an Old Material

Advanced Engineering Materials, EarlyView.
New features on yttria‐stabilized zirconia after exposure at 1500°C: Newly discovered pyramidal structures on an old material. After exposure at 1550°C on the cross section of YSZ new features, namely pyramidal structures are discovered. These structures grow with time, increase in numbers, appear as singularities, are often arranged in strings, and ...
Doris Sebold, Dylan Jennings, Robert Vaßen   +2 more
wiley   +1 more source

Insights of the asynchronous strain evolution of lean coal in uniaxial compression creep

Scientific Reports
Owing to the heterogeneity, discontinuity and complex material structure, typical coal exhibits intricate deformation characteristics during long-term creep processes.
Tingting Cai, Jia Liu, Zengchao Feng, Kai Wang, Yongxing Shen, Yulong Jiang, Bichuan Zhang   +6 more
doaj   +1 more source

Dynamic Compressive Characteristics of Sandstone under Confining Pressure and Radial Gradient Stress with the SHPB Test

Advances in Civil Engineering, 2018
Research on the dynamic compressive characteristics of sandstone under radial gradient stress and confining pressure is conducive to understanding the characteristics of the surrounding rock, especially in an excavation operation for an underground mine ...
Shiming Wang, Yunsi Liu, Jian Zhou, Qiuhong Wu, Shuyi Ma, Zhihua Zhou   +5 more
doaj   +1 more source

Contact mechanical behaviors of radial metal seal for the interval control valve in intelligent well: Modeling and theoretical study

Energy Science & Engineering, 2020
Intelligent wells equipped with the interval control valve (ICV), which have the potential applications to significantly improve oil production or control the water production of wells and fields, are more and more widely utilized in the oilfields.
Yiwei Yang, Hongwu Zhu, Dongsheng He, Changcheng Du, Liangbin Xu, Yufa He, Yan Zheng, Zhewei Ye   +7 more
doaj   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

Advanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares, Nadège Bouchonneau, Christian Jochum, Donald Radford   +3 more
wiley   +1 more source