Results 51 to 60 of about 1,269,792 (269)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Water Vapor Spectroscopy and Thermodynamics Constrain Earth's Tropopause Temperature

AGU Advances
As Earth warms, the tropopause is expected to rise, but predictions of its temperature change are less certain. Longstanding theories employing “gray” radiation tie the tropopause temperature to outgoing longwave radiation (OLR), but this is in contrast ...
Brett A. McKim, Nadir Jeevanjee, Geoffrey K. Vallis, Neil T. Lewis   +3 more
doaj   +1 more source

Silybin Derivatives Produced by γ-Irradiation and Their Tyrosinase Inhibitory Activities

Molecules
Silybin, which belongs to the flavonolignan group, is the major component of the fruit extract of Silybum marianum (common name: milk thistle). Silybin is a medicinal compound with hepatoprotective, antioxidant, and anticancer properties.
Ah-Reum Han, Hyung Won Ryu, Chang Hyun Jin   +2 more
doaj   +1 more source

Hawking Radiation, Unruh Radiation, and the Equivalence Principle [PDF]

Physical Review Letters, 2011
9 pages. Added references and added discussion.
Singleton, Douglas, Wilburn, Steve
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Radiation protection, radiation safety and radiation shielding assessment of HIE-ISOLDE [PDF]

Radiation Protection Dosimetry, 2013
The high intensity and energy ISOLDE (HIE-ISOLDE) project is an upgrade to the existing ISOLDE facility at CERN. The foreseen increase in the nominal intensity and the energy of the primary proton beam of the existing ISOLDE facility aims at increasing the intensity of the produced radioactive ion beams (RIBs).
Y, Romanets, A P, Bernardes, A, Dorsival, I F, Gonçalves, Y, Kadi, S, di Maria, P, Vaz, V, Vlachoudis, J, Vollaire   +8 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prototype solar dome designed to function as a solar calendar

Journal of Asian Architecture and Building Engineering
The experiment aimed to create a prototype of a calendar dome that shows the days of the year using solar light passing through specific holes in the dome’s covering.
Mojtaba Pourbakht, Yoshihiro Kametani
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Non-extensive thermodynamics of the radiation in heterogeneous thermal plasmas

Condensed Matter Physics, 2022
Thermodynamic characteristics of the radiation of condensed combustion products presented in the form of agglomerates of metal-oxide nanoparticles demonstrate deviations from the classical Planck’s law.
G. S. Dragan, V. V. Kutarov, A. Y. Bekshaev   +2 more
doaj   +1 more source