Results 71 to 80 of about 1,269,792 (269)

Use of 2-color flow cytometry to assess radiation-induced genotoxic damage on CHO-KI cells

Brazilian Journal of Radiation Sciences, 2019
The micronucleus assay is an important technique used to evaluate genotoxic damage of chemical or physical agents (as ionizing radiations) on cells, based on quantification of cells bearing micronuclei, which are fragments derived from damage (breakage ...
Luma Ramirez de Carvalho, Letícia Bonfim, Daniel Perez Vieira   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Photon versus Proton Therapy in the Management of Head and Neck Cancer: A Systematic Review

Journal of Clinical and Diagnostic Research
Introduction: Head and Neck Cancers (HNC), particularly Head and Neck Squamous Cell Carcinoma (HNSCC), are major causes of cancer morbidity and mortality. Radiation therapy, commonly using photons, can damage surrounding healthy tissues.
S Sowmya, R Sangavi, R Amritha Sripoo
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Is Gravitational Radiation a Radiation of the Same Level as Electromagnetic Radiation?

Journal of Modern Physics, 2014
The notion of gravitational radiation as a radiation of the same level as the electromagnetic radiation is based on the theoretically proven and experimentally confirmed facts of the existence of stationary states of an electron in its gravitational field, characterized by the gravitational constant K = 1042 G (G is Newtonian gravitational constant ...
Stanislav I. Fisenko, I. S. Fisenko
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The radiative effects of water vapour from terrestrial evapotranspiration

Environmental Research Letters
Water vapour accounts for roughly 50% of the modern greenhouse effect. Over continental regions, evapotranspiration (ET) is often limited by water availability.
M M Lague, G R Quetin, K B Heyblom
doaj   +1 more source

Miniature radiation dosimeter for in vivo radiation measurements

International Journal of Radiation Oncology*Biology*Physics, 1986
We have made initial characterization measurements on a miniature radiation dosimeter which can be used for in vivo radiation measurements. It consists of a radiation sensing field effect transistor (RADFET) mounted in a 0.8 mm OD plastic catheter. The RADFET acts as a dosimeter by storing trapped charge proportional to absorbed dose. The stored charge
R C, Hughes, D, Huffman, J V, Snelling, T E, Zipperian, A J, Ricco, C A, Kelsey   +5 more
openaire   +2 more sources