Results 71 to 80 of about 4,408,475 (358)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R. Rheingold, Gerald Wertheim, Moe Takeda, Daniel J. Zheng, Kaitlin Devine   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Coupled experiment/simulation approach for the design of radiation-hardened rare-earth doped optical fibers and amplifiers [PDF]

, 2011
We developed an approach to design radiation-hardened rare earth -doped fibers and amplifiers. This methodology combines testing experiments on these devices with particle swarm optimization (PSO) calculations.
F. Prudenzano, Mescia, L, Vivona, M., Girard, S, Boukenter, Aziz, A. Boukenter, Goiffon, V, Cannas, M., V. Goiffon, Mescia, Luciano, Boukenter, A, L. Mescia, Vivona, Marilena, Mescia, L., R. Boscaino, Cadier, B., P. Paillet, Paillet, P., Y. Ouerdane, Boukenter, A., Paillet, P, Paillet, Philippe, Marcandella, C, Cadier, Benoît, S. Girard, A. Laurent, Laurent, A, Robin, T, C. Marcandella, Goiffon, Vincent, Cadier, B, Ouerdane, Y., Ouerdane, Y, Girard, Sylvain, Prudenzano F, Robin, Thierry, F. Robin, Prudenzano, F, Laurent, Arnaud, Boscaino, Roberto, T. Robin, Robin, T., B. Cadier, Marcandella, C., Goiffon, V., Cannas, Marco, M. Cannas, Prudenzano, F., Boscaino, R., Prudenzano, Francesco, Ouerdane, Youcef, M. Vivona, Girard, Sébastien, Marcandella, Claude, Laurent, A.   +54 more
core   +1 more source

Irradiation and Alterations in Hippocampal DNA Methylation

Epigenomes
The response of the brain to radiation is important for cancer patients receiving whole or partial brain irradiation or total body irradiation, those exposed to irradiation as part of a nuclear accident or a nuclear war or terrorism event, and for ...
Soren Impey, Jacob Raber
doaj   +1 more source

Ionization and Radiation [PDF]

Science, 1920
n ...
openaire   +2 more sources

Improving the Clinical Treatment of Vulnerable Populations in Radiation Oncology

, 2020
The increasing role of radiation oncology in optimal cancer care treatment brings to mind the adage that power is never a gift, but a responsibility. A significant part of the responsibility we in radiation oncology bear is how to ensure optimal access ...
Zeitlin, Ross, Miller, Robert C., Deville, Curtiland, McClelland, Shearwood, III., McClelland, Shearwood, Siker, Malika L, Suneja, Gita, Siker, Malika L., Petereit, Daniel G, Petereit, Daniel G., Miller, Robert C, Takita, Cristiane   +11 more
core   +1 more source

Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.

, 2021
Exposure of the gastrointestinal (GI) tract to ionizing radiation can cause acute and delayed injury. However, critical cellular targets that regulate the development of radiation-induced GI injury remain incompletely understood.
Kirsch, David G, Lee, Chang-Lung, Daniel, Andrea R, Silva Campos, Lorraine Da, Holbrook, Matt, Badea, Cristian T, Borst, Luke B, Hasapis, Stephanie, Brownstein, Jeremy, Ma, Yan   +9 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source