Results 31 to 40 of about 138,699 (259)

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

MODIFIKASI SENSOR KECEPATAN ANGIN BEDA SUHU BERBASIS MIKROKONTROLER DENGAN TRANSMISI JARAK JAUH SEBAGAI PENGUKUR POTENSI PEMBANGKIT LISTRIK TENAGA ANGIN

Jurnal Pendidikan Fisika Indonesia, 2011
Modifikasi sensor kecepatan angin beda suhu bertujuan untuk memperbaiki kinerja sensor dengan menstabilkan prosespenginderaan kecepatan angin dan transmisi data jarak jauh, yang dilakukan dengan menambahkan mikrokontroler AT89S52sebagai basis operasi ...
A. A. Harnawan, A. L. Assadat, F. N. Jannah   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tetris-inspired detector with neural network for radiation mapping

Nature Communications
Radiation mapping has attracted widespread research attention and increased public concerns on environmental monitoring. Regarding materials and their configurations, radiation detectors have been developed to identify the position and strength of the ...
Ryotaro Okabe, Shangjie Xue, Jayson R. Vavrek, Jiankai Yu, Ryan Pavlovsky, Victor Negut, Brian J. Quiter, Joshua W. Cates, Tongtong Liu, Benoit Forget, Stefanie Jegelka, Gordon Kohse, Lin-wen Hu, Mingda Li   +13 more
doaj   +1 more source

Study on the factors influencing the output response of LYSO:Ce electron radiation detector

He jishu
BackgroundThe total dose effect of ionization on satellites in Geostationary Earth Orbit (GEO) is caused by space particle radiation in GEO.PurposeThis study aims to combine high-performance cerium-doped yttrium-lutetium silicate (LYSO:Ce) crystals with ...
MENG Zong, LIU Hao, LIU Jingbo, WANG Hang   +3 more
doaj   +1 more source

Polycrystalline CVD diamond detector: Fast response and high sensitivity with large area

AIP Advances, 2014
Polycrystalline diamond was successfully used to fabricate a large area (diameter up to 46 mm) radiation detector. It was proven that the developed detector shows a fast pulsed response time and a high sensitivity, therefore its rise time is lower than 5
Linyue Liu, Xiaoping Ouyang, Jianfu Zhang, Xianpeng Zhang, Yunhong Zhong   +4 more
doaj   +1 more source

Simulation-Based Analysis of the Effect of Alpha Irradiation on GaN Particle Detectors

Micromachines, 2023
Radiation-hardened semiconductor GaN has drawn considerable attention owing to its excellent properties such as large displacement energy. Many studies have focused on evaluating the degradation of GaN-based power device performance by proton beam or ...
Jianming Lei, Nan Wang, Rukai Jiang, Qianyu Hou   +3 more
doaj   +1 more source