Results 71 to 80 of about 272,094 (281)

In–HgCdTe–In structures with symmetric nonlinear I–V characteristics for sub-THz direct detection

open access: yesSemiconductor Physics, Quantum Electronics & Optoelectronics, 2017
This paper reports on the development and investigations of In–Hg1–xCdxTe–In structures with symmetric nonlinear I–V curves that are sensitive to sub-terahertz radiation.
N.I. Kukhtaruk   +4 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Characterisation of highly irradiated 3D trench silicon pixel sensors for 4D tracking with 10 ps timing accuracy

open access: yesFrontiers in Physics
3D trench silicon pixel sensors, recently developed by the TimeSPOT collaboration, have shown excellent performance in terms of spatial resolution, timing precision and detection efficiency.
F. Borgato   +17 more
doaj   +1 more source

Readout and performance of thick CZT strip detectors with orthogonal coplanar anodes [PDF]

open access: yes, 2002
We report progress in the study of CZT strip detectors featuring orthogonal coplanar anode contacts. The work includes laboratory and simulation studies aimed at optimizing and developing compact, efficient, high performance detector modules for 0.05 to ...
Donmez, B   +8 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Applications of 4H Silicon Carbide Radiation Detectors in Fission and Fusion Reactor Environments [PDF]

open access: yesEPJ Web of Conferences
Semiconductor radiation detectors based on the 4H polytype of Silicon Carbide (4H-SiC) have many advantages for high-temperature, high-radiation and mixed-radiation applications.
Ruddy Frank H.   +5 more
doaj   +1 more source

Correlation between radiation processes in silicon and long-time degradation of detectors for high energy physics experiments [PDF]

open access: yes, 2006
In this contribution, the correlation between fundamental interaction processes induced by radiation in silicon and observable effects which limit the use of silicon detectors in high energy physics experiments is investigated in the frame of a ...
Al-Mushadani   +10 more
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

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