Results 1 to 10 of about 2,871,612 (244)

FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair

Cell Reports, 2014
The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand ...
Junya Unno, Akiko Itaya, Masato Taoka, Koichi Sato, Junya Tomida, Wataru Sakai, Kaoru Sugasawa, Masamichi Ishiai, Tsuyoshi Ikura, Toshiaki Isobe, Hitoshi Kurumizaka, Minoru Takata   +11 more
doaj   +1 more source

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells

Stem Cell Reports, 2014
Germ cells are thought to exhibit a unique DNA damage response that differs from that of somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival of spermatogonial stem cells (SSCs) after irradiation.
Kei Ishii, Masamichi Ishiai, Hiroko Morimoto, Mito Kanatsu-Shinohara, Ohtsura Niwa, Minoru Takata, Takashi Shinohara   +6 more
doaj   +1 more source

Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

Cells, 2020
Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated.
Xiaoyu Pu, Siyang Ma, Yan Gao, Tiankai Xu, Pengyu Chang, Lihua Dong   +5 more
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Study of Polymorphic Transformation Processes and Their Influence in Polycrystalline ZrO₂ Ceramics upon Irradiation with Heavy Ions

Ceramics, 2023
The aim of this work was to study the mechanisms of polymorphic transformations in ZrO2 ceramics under irradiation with heavy ions, as well as to determine the nature of structural distortions in the case of t-ZrO2 → c-ZrO2 type transformations and ...
Artem L. Kozlovskiy, Mahambet Alin, Daryn B. Borgekov   +2 more
doaj   +1 more source

Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment

Frontiers in Physiology, 2019
Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the palliative setting. Radiotherapy efficacy could be improved in combination with drugs that regulate
Shahd Fouad, Owen S. Wells, Mark A. Hill, Vincenzo D’Angiolella   +3 more
doaj   +1 more source

The basics of radiation damage in crystalline silicon networks by NIEL

Brazilian Journal of Radiation Sciences, 2021
Basically, radiation can cause two effects on materials: ionization and non-ionization. This work presented the theory involved in defects caused by non-ionization, known as NIEL, with a focus on silicon materials.
Carla Daruich de Souza, Jong Bun KIM, Jin Joo KIM, Jin KIM, Wanook JI, Kwang Jae SON, Sang Mu CHOI, Gu Jin KANG, Jin Te HONG   +8 more
doaj   +1 more source

Evaluation of radiation damage exposure for low alloy steel in J-9 irradiation channel of Argonauta reactor

Brazilian Journal of Radiation Sciences, 2023
The operation of nuclear facilities must satisfy the nuclear safety requirements. An analysis of the components of these facilities focuses on the structural materials. In this scenario, several types of alloys are employed in their construction.
Jonnathan Ogihara, Pedro Benevides Ribeiro da Silva, Fernando Manuel Araújo Moreira   +2 more
doaj   +1 more source

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

Nature Communications, 2017
ATR kinase activity is essential for slowing replication forks and preventing DNA replication in cells with DNA damage. Here the authors show that ATR inhibition leads to Cdc7 phosphorylation of GINS, leading to origin firing.
Tatiana Moiseeva, Brian Hood, Sandy Schamus, Mark J. O’Connor, Thomas P. Conrads, Christopher J. Bakkenist   +5 more
doaj   +1 more source

Prevalence of cognitive impairment and its related factors among Chinese older adults: an analysis based on the 2018 CHARLS data

Frontiers in Public Health
BackgroundCognitive impairment is a major public health concern in aging societies. This study aimed to investigate the prevalence of cognitive impairment and its associated factors among Chinese adults aged 60 years and older using data from the 2018 ...
Xueqin Wu, Xueqin Wu, Yufu Tang, Yushan He, Qiwei Wang, Qiwei Wang, Yinhui Wang, Xiujun Qin   +7 more
doaj   +1 more source

A Perspective on Molecular Structure and Bond-Breaking in Radiation Damage in Serial Femtosecond Crystallography

Crystals, 2020
X-ray free-electron lasers (XFELs) have a unique capability for time-resolved studies of protein dynamics and conformational changes on femto- and pico-second time scales.
Carl Caleman, Francisco Jares Junior, Oscar Grånäs, Andrew V. Martin   +3 more
doaj   +1 more source