Results 21 to 30 of about 718,807 (247)

Post-Irradiation Thymic Regeneration in B6C3F1 Mice Is Age Dependent and Modulated by Activation of the PI3K-AKT-mTOR Pathway

Biology, 2022
The risk of radiation-induced carcinogenesis depends on age at exposure. We previously reported principal causative genes in lymphomas arising after infant or adult exposure to 4-fractionated irradiation as Pten or Ikzf1, respectively, suggesting that ...
Masaaki Sunaoshi, Benjamin J. Blyth, Yi Shang, Chizuru Tsuruoka, Takamitsu Morioka, Mayumi Shinagawa, Mari Ogawa, Yoshiya Shimada, Akira Tachibana, Daisuke Iizuka, Shizuko Kakinuma   +10 more
doaj   +1 more source

ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response

Radiation Oncology, 2022
Background The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene family, and ΔNp63α, a TP63 splicing
Ken-ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu, Akira Sakai   +7 more
doaj   +1 more source

COVID-19-Associated Pneumonia: Radiobiological Insights

Frontiers in Pharmacology, 2021
The evolution of SARS-CoV-2 pneumonia to acute respiratory distress syndrome is linked to a virus-induced “cytokine storm”, associated with systemic inflammation, coagulopathies, endothelial damage, thrombo-inflammation, immune system deregulation and ...
Sabine François, Carole Helissey, Sophie Cavallero, Michel Drouet, Nicolas Libert, Jean-Marc Cosset, Eric Deutsch, Eric Deutsch, Lydia Meziani, Lydia Meziani, Cyrus Chargari, Cyrus Chargari, Cyrus Chargari   +12 more
doaj   +1 more source

Effects of Omitting Non-confounding Predictors From General Relative-Risk Models for Binary Outcomes

Journal of Epidemiology, 2019
Background: The effects, in terms of bias and precision, of omitting non-confounding predictive covariates from generalized linear models have been well studied, and it is known that such omission results in attenuation bias but increased precision with ...
John Cologne, Kyoji Furukawa, Eric J. Grant, Robert D. Abbott   +3 more
doaj   +1 more source

Critical Review on Toxicological Mechanisms Triggered by Inhalation of Alumina Nanoparticles on to the Lungs

Biomedicines, 2022
Alumina nanoparticles (Al2O3 NPs) can be released in occupational environments in different contexts such as industry, defense, and aerospace. Workers can be exposed by inhalation to these NPs, for instance, through welding fumes or aerosolized ...
Samir Dekali, Alexandra Bourgois, Sabine François   +2 more
doaj   +1 more source

Reproducibility of Age at Menarche Gathered From Mail Questionnaires: A Report From the Life Span Study

Journal of Epidemiology
Background: Menarche timing may affect female health. While previous studies evaluated self-reported age at menarche reproducibility, they did not assess types of respondents.
Yuko Kadowaki, Alina V. Brenner, Michiko Yamada, Hiromi Sugiyama, Mai Utada, Munechika Misumi, Ritsu Sakata   +6 more
doaj   +1 more source

Spermidine alleviates thymopoiesis defects and aging of the peripheral T-cell population in mice after radiation exposure

Experimental Gerontology
The T cell aging process can be modified by genotoxic factors, including ionizing radiation, and metabolic controls, such as caloric restriction; the former accelerates and the latter retards the process.
Kengo Yoshida, Zhenqiu Liu, Yoshiko Kubo, Masahiko Miura, Mika Yamaoka, Hiroko Nagamura, Munechika Misumi, Yoichiro Kusunoki   +7 more
doaj   +1 more source

Double-strand breaks in lymphocyte DNA of humans exposed to [18F]fluorodeoxyglucose and the static magnetic field in PET/MRI

EJNMMI Research, 2020
Background Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution.
Gunnar Brix, Elisabeth Günther, Ute Rössler, David Endesfelder, Alexandra Kamp, Ambros Beer, Matthias Eiber   +6 more
doaj   +1 more source

Advanced Omics and Radiobiological Tissue Archives: The Future in the Past

Applied Sciences, 2021
Archival formalin-fixed, paraffin-embedded (FFPE) tissues and their related diagnostic records are an invaluable source of biological information. The archival samples can be used for retrospective investigation of molecular fingerprints and biomarkers ...
Omid Azimzadeh, Maria Gomolka, Mandy Birschwilks, Shin Saigusa, Bernd Grosche, Simone Moertl   +5 more
doaj   +1 more source

Prevalence of tanning equipment use among Canadians

Preventive Medicine Reports, 2021
The objective of this study was to collect prevalence estimates of indoor tanning usage and associated injuries in Canada. The rapid response component of the 2019 Canadian Community Health Survey collected data on the use of tanning equipment in the ...
Sami S. Qutob, James P. McNamee, Orly Brion   +2 more
doaj   +1 more source