Results 151 to 160 of about 7,527,769 (291)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Inhibition of eCIRP Attenuates Inflammation and Gut Injury After Radiation Combined Injury with Sepsis. [PDF]

Med Sci (Basel)
Zhang F, Ma G, Jin H, Jacob A, Brenner M, Wang P.   +5 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Multiplex Immunofluorescence-Based Investigation of the Interventional Effect of Bisdemethoxycurcumin on Glial Cell Polarization in Radiation-Induced Brain Injury. [PDF]

Biomolecules
Zhang T, Geng Z, Chen J, Li J, Han Z, Han F, Li J.   +6 more
europepmc   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Occupational diseases in dentistry: Prevention. [PDF]

J Clin Exp Dent
López-Carriches C, Taheri R, Mateos-Moreno V, García-Marqués A, Meniz-García C, Madrigal-Martínez-Pereda C, Leco-Berrocal I.   +6 more
europepmc   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Application of medical gases in prevention and treatment of electromagnetic radiation injury. [PDF]

Med Gas Res
Xing Y, Chen F, Liu G, Bao S, Zhang X, Guo Z, Shou Z, Guo J.   +7 more
europepmc   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source