Results 151 to 160 of about 547,234 (309)

Radiation Oncology [PDF]

, 2020
Jessica W. Lee, David G. Kirsch
openaire   +2 more sources

Clinical governance in radiation oncology. [PDF]

Rep Pract Oncol Radiother
Malicki J, Guedea F, Krengli M.
europepmc   +1 more source

Quantitative FDG-PET/CT predicts local recurrence and survival for squamous cell carcinoma of the anus [PDF]

, 2017
Cardenas, Michael L, DeWees, Todd A, Markovina, Stephanie, Mazur, Thomas R, Olsen, Jeffrey R, Parikh, Parag J, Spencer, Christopher R, Weiner, Ashley A   +7 more
core   +2 more sources

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Simulation training in radiation oncology. [PDF]

J Appl Clin Med Phys
Schell MC, Beavis AW, Brown DW, Milano M, O'Neill M, Yu Y, Pavord DC, Dunscombe P.   +7 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

A Retrospective Evaluation of Setup Errors Associated with Respiratory Motion Management Techniques in Stereotactic Body Radiation Therapy for Hepatic Malignancies

Journal of Hepatocellular Carcinoma
Ji-Hua Han,* Dong-Cheng He,* Xiao-Ye Zhang, Yan Zhang, Jun Hong, Ting-Ting Shi, Zhi-Jian Zhu Department of Radiation Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, 223300 ...
Han JH, He DC, Zhang XY, Zhang Y, Hong J, Shi TT, Zhu ZJ   +6 more
doaj  

Radiation oncology as a complex adaptive system. [PDF]

Front Oncol
Bakhtiari M.
europepmc   +1 more source

Superior metastasis-free survival for patients with high-risk prostate cancer treated with definitive radiation therapy compared to radical prostatectomy: A propensity score-matched analysis [PDF]

, 2018
Badiyan, Shahed, Gay, Hiram A, Markovina, Stephanie, Meeks, Marshall W, Michalski, Jeff, Paradis, Alethea, Sandhu, Gurdarshan, Vetter, Joel   +7 more
core   +2 more sources

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source